Elevated maternal serum α-fetoprotein levels and oligohydramnios: Poor prognosis for pregnancy outcome

S. N. Dyer, B. K. Burton, L. H. Nelson

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The outcome of 21 pregnancies with elevated maternal serum α-fetoprotein levels associated with oligohydramnios was studied. Seven of the 21 pregnancies ended in spontaneous abortion or intrauterine fetal death before week 24 of pregnancy. Five patients experienced premature labor between 24 and 26 weeks of gestation; each fetus was either stillborn or died in the immediate neonatal period. Four patients were delivered of infants after 32 weeks of gestation; each infant was either stillborn or died in the immediate neonatal period. Four patients electively had their pregnancies terminated. One patient was delivered at term of a healthy, growth retarded male infant who on follow-up at age 17 months was developmentally normal. Only three cases were associated with a fetal defect. Patients should be counseled that, even in the absence of a demonstrable cause for diminished amniotic fluid on ultrasonography, raised maternal serum α-fetoprotein levels coupled with oligohydramnios seem to carry a poor prognosis.

Original languageEnglish (US)
Pages (from-to)336-339
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Volume157
Issue number2
DOIs
StatePublished - Jan 1 1987

Keywords

  • Maternal serum α-fetoprotein
  • oligohydramnios

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Elevated maternal serum α-fetoprotein levels and oligohydramnios: Poor prognosis for pregnancy outcome'. Together they form a unique fingerprint.

Cite this