Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure

D. A. Tonetti; M. Morrow; N. Kidwai; A. Gupta; S. Badve

doi:10.1038/sj.bjc.6600923

Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure

D. A. Tonetti^*, M. Morrow, N. Kidwai, A. Gupta, S. Badve

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant turnout growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCα expression may predict TAM treatment failure.

Original language	English (US)
Pages (from-to)	1400-1402
Number of pages	3
Journal	British Journal of Cancer
Volume	88
Issue number	9
DOIs	https://doi.org/10.1038/sj.bjc.6600923
State	Published - May 6 2003

Keywords

Breast cancer
Protein kinase C alpha
Tamoxifen resistance

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6600923

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title = "Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure",

abstract = "We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant turnout growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCα expression may predict TAM treatment failure.",

keywords = "Breast cancer, Protein kinase C alpha, Tamoxifen resistance",

author = "Tonetti, {D. A.} and M. Morrow and N. Kidwai and A. Gupta and S. Badve",

note = "Funding Information: These studies were supported by NIH/NCI Grant R01CA79847 and the Avon Foundation awarded to DAT.",

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AU - Tonetti, D. A.

AU - Morrow, M.

AU - Kidwai, N.

AU - Gupta, A.

AU - Badve, S.

N1 - Funding Information: These studies were supported by NIH/NCI Grant R01CA79847 and the Avon Foundation awarded to DAT.

PY - 2003/5/6

Y1 - 2003/5/6

N2 - We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant turnout growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCα expression may predict TAM treatment failure.

AB - We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant turnout growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCα expression may predict TAM treatment failure.

KW - Breast cancer

KW - Protein kinase C alpha

KW - Tamoxifen resistance

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Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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