Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure

D. A. Tonetti*, M. Morrow, N. Kidwai, A. Gupta, S. Badve

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant turnout growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCα expression may predict TAM treatment failure.

Original languageEnglish (US)
Pages (from-to)1400-1402
Number of pages3
JournalBritish Journal of Cancer
Volume88
Issue number9
DOIs
StatePublished - May 6 2003

Keywords

  • Breast cancer
  • Protein kinase C alpha
  • Tamoxifen resistance

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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