Elevated soluble vascular cell adhesion molecule-1 is associated with cerebrovascular resistance and cognitive function

Achille E. Tchalla; Gregory A. Wellenius; Farzaneh A. Sorond; Margaret Gagnon; Ikechukwu Iloputaife; Thomas G. Travison; Thierry Dantoine; Lewis A. Lipsitz

doi:10.1093/gerona/glw099

Elevated soluble vascular cell adhesion molecule-1 is associated with cerebrovascular resistance and cognitive function

Achille E. Tchalla^*, Gregory A. Wellenius, Farzaneh A. Sorond, Margaret Gagnon, Ikechukwu Iloputaife, Thomas G. Travison, Thierry Dantoine, Lewis A. Lipsitz

^*Corresponding author for this work

Neurology

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25 Scopus citations

Abstract

Background: Elevated plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) is a presumed marker of endothelial dysfunction, both in the brain and systemic circulation. Impairments in memory and cognition have been associated with cardiovascular diseases, but little is known about their relationships to abnormal cerebral endothelial function. Methods: We studied the cross-sectional association between sVCAM-1 and markers of cerebrovascular hemodynamics and cognitive function in 680 community-dwelling participants in the MOBILIZE Boston Study, aged 65 years and older. Cognitive function was assessed using the Hopkins Verbal Learning Memory Test and Trail Making Tests (TMTs) A and B. Global cognitive impairment was defined as Mini-Mental State Examination (MMSE) score less than 24. sVCAM-1 was measured by ELISA assay. Beat-To-beat blood flow velocity (BFV) and cerebrovascular resistance (CVR = mean arterial pressure / BFV) in the middle cerebral artery were assessed at rest by transcranial Doppler ultrasound. Results: sVCAM-1 concentrations were higher among participants with an MMSE score <24 versus ≥24 (1,201 ± 417 vs 1,122 ± 494 ng/ mL). In regression models adjusted for sociodemographic characteristics and health conditions, increasing levels of sVCAM-1 were linearly associated with higher resting CVR (p = .006) and lower performance on the Hopkins Verbal Learning Memory (immediate recall and delayed recall) and adjusted TMT B tests (p < .05). Higher levels of sVCAM-1 were also associated with global cognitive impairment on the MMSE (odds ratio = 3.9; 95% confidence interval: 1.4-10.9; p = .011). Conclusions: In this cohort of elderly participants, we observed a cross-sectional association between elevated sVCAM-1 levels and both cognitive impairment and increased cerebrovascular resistance. Longitudinal studies are needed to determine whether elevated sVCAM-1 is a cause or consequence of cerebrovascular damage.

Original language	English (US)
Pages (from-to)	560-566
Number of pages	7
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	72
Issue number	4
DOIs	https://doi.org/10.1093/gerona/glw099
State	Published - 2017

Funding

This work was supported by grants P01 AG04390, R01 AG025037, and R01 AG041785 from the National Institute on Aging, NS085002 from the National Institute of Neurological Disorders and Stroke, and R01ES020871 and R00ES015774 from the National Institute for Environmental Health Sciences.

Keywords

Cerebrovascular resistance
Cognitive impairment
Endothelium
Executive function
sVCAM-1

ASJC Scopus subject areas

Geriatrics and Gerontology
Aging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/gerona/glw099

Cite this

Tchalla, A. E., Wellenius, G. A., Sorond, F. A., Gagnon, M., Iloputaife, I., Travison, T. G., Dantoine, T., & Lipsitz, L. A. (2017). Elevated soluble vascular cell adhesion molecule-1 is associated with cerebrovascular resistance and cognitive function. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 72(4), 560-566. https://doi.org/10.1093/gerona/glw099

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title = "Elevated soluble vascular cell adhesion molecule-1 is associated with cerebrovascular resistance and cognitive function",

abstract = "Background: Elevated plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) is a presumed marker of endothelial dysfunction, both in the brain and systemic circulation. Impairments in memory and cognition have been associated with cardiovascular diseases, but little is known about their relationships to abnormal cerebral endothelial function. Methods: We studied the cross-sectional association between sVCAM-1 and markers of cerebrovascular hemodynamics and cognitive function in 680 community-dwelling participants in the MOBILIZE Boston Study, aged 65 years and older. Cognitive function was assessed using the Hopkins Verbal Learning Memory Test and Trail Making Tests (TMTs) A and B. Global cognitive impairment was defined as Mini-Mental State Examination (MMSE) score less than 24. sVCAM-1 was measured by ELISA assay. Beat-To-beat blood flow velocity (BFV) and cerebrovascular resistance (CVR = mean arterial pressure / BFV) in the middle cerebral artery were assessed at rest by transcranial Doppler ultrasound. Results: sVCAM-1 concentrations were higher among participants with an MMSE score <24 versus ≥24 (1,201 ± 417 vs 1,122 ± 494 ng/ mL). In regression models adjusted for sociodemographic characteristics and health conditions, increasing levels of sVCAM-1 were linearly associated with higher resting CVR (p = .006) and lower performance on the Hopkins Verbal Learning Memory (immediate recall and delayed recall) and adjusted TMT B tests (p < .05). Higher levels of sVCAM-1 were also associated with global cognitive impairment on the MMSE (odds ratio = 3.9; 95% confidence interval: 1.4-10.9; p = .011). Conclusions: In this cohort of elderly participants, we observed a cross-sectional association between elevated sVCAM-1 levels and both cognitive impairment and increased cerebrovascular resistance. Longitudinal studies are needed to determine whether elevated sVCAM-1 is a cause or consequence of cerebrovascular damage.",

keywords = "Cerebrovascular resistance, Cognitive impairment, Endothelium, Executive function, sVCAM-1",

author = "Tchalla, {Achille E.} and Wellenius, {Gregory A.} and Sorond, {Farzaneh A.} and Margaret Gagnon and Ikechukwu Iloputaife and Travison, {Thomas G.} and Thierry Dantoine and Lipsitz, {Lewis A.}",

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year = "2017",

doi = "10.1093/gerona/glw099",

language = "English (US)",

volume = "72",

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Tchalla, AE, Wellenius, GA, Sorond, FA, Gagnon, M, Iloputaife, I, Travison, TG, Dantoine, T & Lipsitz, LA 2017, 'Elevated soluble vascular cell adhesion molecule-1 is associated with cerebrovascular resistance and cognitive function', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 72, no. 4, pp. 560-566. https://doi.org/10.1093/gerona/glw099

Elevated soluble vascular cell adhesion molecule-1 is associated with cerebrovascular resistance and cognitive function. / Tchalla, Achille E.; Wellenius, Gregory A.; Sorond, Farzaneh A. et al.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 72, No. 4, 2017, p. 560-566.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Elevated soluble vascular cell adhesion molecule-1 is associated with cerebrovascular resistance and cognitive function

AU - Tchalla, Achille E.

AU - Wellenius, Gregory A.

AU - Sorond, Farzaneh A.

AU - Gagnon, Margaret

AU - Iloputaife, Ikechukwu

AU - Travison, Thomas G.

AU - Dantoine, Thierry

AU - Lipsitz, Lewis A.

PY - 2017

Y1 - 2017

N2 - Background: Elevated plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) is a presumed marker of endothelial dysfunction, both in the brain and systemic circulation. Impairments in memory and cognition have been associated with cardiovascular diseases, but little is known about their relationships to abnormal cerebral endothelial function. Methods: We studied the cross-sectional association between sVCAM-1 and markers of cerebrovascular hemodynamics and cognitive function in 680 community-dwelling participants in the MOBILIZE Boston Study, aged 65 years and older. Cognitive function was assessed using the Hopkins Verbal Learning Memory Test and Trail Making Tests (TMTs) A and B. Global cognitive impairment was defined as Mini-Mental State Examination (MMSE) score less than 24. sVCAM-1 was measured by ELISA assay. Beat-To-beat blood flow velocity (BFV) and cerebrovascular resistance (CVR = mean arterial pressure / BFV) in the middle cerebral artery were assessed at rest by transcranial Doppler ultrasound. Results: sVCAM-1 concentrations were higher among participants with an MMSE score <24 versus ≥24 (1,201 ± 417 vs 1,122 ± 494 ng/ mL). In regression models adjusted for sociodemographic characteristics and health conditions, increasing levels of sVCAM-1 were linearly associated with higher resting CVR (p = .006) and lower performance on the Hopkins Verbal Learning Memory (immediate recall and delayed recall) and adjusted TMT B tests (p < .05). Higher levels of sVCAM-1 were also associated with global cognitive impairment on the MMSE (odds ratio = 3.9; 95% confidence interval: 1.4-10.9; p = .011). Conclusions: In this cohort of elderly participants, we observed a cross-sectional association between elevated sVCAM-1 levels and both cognitive impairment and increased cerebrovascular resistance. Longitudinal studies are needed to determine whether elevated sVCAM-1 is a cause or consequence of cerebrovascular damage.

AB - Background: Elevated plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) is a presumed marker of endothelial dysfunction, both in the brain and systemic circulation. Impairments in memory and cognition have been associated with cardiovascular diseases, but little is known about their relationships to abnormal cerebral endothelial function. Methods: We studied the cross-sectional association between sVCAM-1 and markers of cerebrovascular hemodynamics and cognitive function in 680 community-dwelling participants in the MOBILIZE Boston Study, aged 65 years and older. Cognitive function was assessed using the Hopkins Verbal Learning Memory Test and Trail Making Tests (TMTs) A and B. Global cognitive impairment was defined as Mini-Mental State Examination (MMSE) score less than 24. sVCAM-1 was measured by ELISA assay. Beat-To-beat blood flow velocity (BFV) and cerebrovascular resistance (CVR = mean arterial pressure / BFV) in the middle cerebral artery were assessed at rest by transcranial Doppler ultrasound. Results: sVCAM-1 concentrations were higher among participants with an MMSE score <24 versus ≥24 (1,201 ± 417 vs 1,122 ± 494 ng/ mL). In regression models adjusted for sociodemographic characteristics and health conditions, increasing levels of sVCAM-1 were linearly associated with higher resting CVR (p = .006) and lower performance on the Hopkins Verbal Learning Memory (immediate recall and delayed recall) and adjusted TMT B tests (p < .05). Higher levels of sVCAM-1 were also associated with global cognitive impairment on the MMSE (odds ratio = 3.9; 95% confidence interval: 1.4-10.9; p = .011). Conclusions: In this cohort of elderly participants, we observed a cross-sectional association between elevated sVCAM-1 levels and both cognitive impairment and increased cerebrovascular resistance. Longitudinal studies are needed to determine whether elevated sVCAM-1 is a cause or consequence of cerebrovascular damage.

KW - Cerebrovascular resistance

KW - Cognitive impairment

KW - Endothelium

KW - Executive function

KW - sVCAM-1

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SN - 1079-5006

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JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

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ER -

Elevated soluble vascular cell adhesion molecule-1 is associated with cerebrovascular resistance and cognitive function

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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