ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL

Stephanie E. Kong, Charles A S Banks, Ali Shilatifard, Joan Weliky Conaway, Ronald C. Conaway*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many sites along DNA. In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity. Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase II transcription.

Original languageEnglish (US)
Pages (from-to)10094-10098
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number29
DOIs
StatePublished - Jul 19 2005

Keywords

  • Elongation
  • Transcription
  • Transcription factor
  • mRNA synthesis

ASJC Scopus subject areas

  • General

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