TY - GEN
T1 - EM fields comparison between planar vs. solenoidal μmS coil designs for nerve stimulation
AU - Bonmassar, Giorgio
AU - Golestanirad, Laleh
N1 - Funding Information:
*Research supported by the National Institutes of Health.
Funding Information:
This work was supported by the Harvard Catalyst and NIH grants R43MH107037 and K99EB021320,.
Publisher Copyright:
© 2017 IEEE.
PY - 2017/9/13
Y1 - 2017/9/13
N2 - Micro-magnetic stimulation (μMS) is an emerging neurostimulation technology that promises to revolutionize the therapeutic stimulation of the human nervous system. μMS uses sub-millimeter sized coils that can be implemented in the central nervous system to elicit neuronal activation using magnetically induced electric currents. By their microscopic size, μMS coils can be acutely implanted in deep brain structures to deliver therapeutic stimulation with effects analogous to those achieved by state-of-the-art deep brain stimulation (DBS). However, μMS technology has inherent advantages that make it particularly appealing for clinical applications. Specifically, μMS induces a focal electric current in the tissue, limiting the extent of activation to a few hundred microns. We recently demonstrated the feasibility of using μMS to elicit neuronal activation in vitro [1], as well as the possibility of activating neuronal circuitry on the system level in rodents [2]. As μMS is a novel technology, its mechanism(s) of nerve activation, induced field characteristics, and optimum topological features are yet to be explored. In this regard, numerical simulations play a crucially important role, because they provide an insight into spatial distribution of induced electric fields, which in turn, dictate the dynamics of nerve stimulation. Here we report results of numerical simulations to predict the nerve-stimulation performance of different μMS geometries.
AB - Micro-magnetic stimulation (μMS) is an emerging neurostimulation technology that promises to revolutionize the therapeutic stimulation of the human nervous system. μMS uses sub-millimeter sized coils that can be implemented in the central nervous system to elicit neuronal activation using magnetically induced electric currents. By their microscopic size, μMS coils can be acutely implanted in deep brain structures to deliver therapeutic stimulation with effects analogous to those achieved by state-of-the-art deep brain stimulation (DBS). However, μMS technology has inherent advantages that make it particularly appealing for clinical applications. Specifically, μMS induces a focal electric current in the tissue, limiting the extent of activation to a few hundred microns. We recently demonstrated the feasibility of using μMS to elicit neuronal activation in vitro [1], as well as the possibility of activating neuronal circuitry on the system level in rodents [2]. As μMS is a novel technology, its mechanism(s) of nerve activation, induced field characteristics, and optimum topological features are yet to be explored. In this regard, numerical simulations play a crucially important role, because they provide an insight into spatial distribution of induced electric fields, which in turn, dictate the dynamics of nerve stimulation. Here we report results of numerical simulations to predict the nerve-stimulation performance of different μMS geometries.
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U2 - 10.1109/EMBC.2017.8037630
DO - 10.1109/EMBC.2017.8037630
M3 - Conference contribution
C2 - 29060671
AN - SCOPUS:85032201033
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 3576
EP - 3579
BT - 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
Y2 - 11 July 2017 through 15 July 2017
ER -