Abstract
Micro-magnetic stimulation (μMS) is an emerging neurostimulation technology that promises to revolutionize the therapeutic stimulation of the human nervous system. μMS uses sub-millimeter sized coils that can be implemented in the central nervous system to elicit neuronal activation using magnetically induced electric currents. By their microscopic size, μMS coils can be acutely implanted in deep brain structures to deliver therapeutic stimulation with effects analogous to those achieved by state-of-the-art deep brain stimulation (DBS). However, μMS technology has inherent advantages that make it particularly appealing for clinical applications. Specifically, μMS induces a focal electric current in the tissue, limiting the extent of activation to a few hundred microns. We recently demonstrated the feasibility of using μMS to elicit neuronal activation in vitro [1], as well as the possibility of activating neuronal circuitry on the system level in rodents [2]. As μMS is a novel technology, its mechanism(s) of nerve activation, induced field characteristics, and optimum topological features are yet to be explored. In this regard, numerical simulations play a crucially important role, because they provide an insight into spatial distribution of induced electric fields, which in turn, dictate the dynamics of nerve stimulation. Here we report results of numerical simulations to predict the nerve-stimulation performance of different μMS geometries.
Original language | English (US) |
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Title of host publication | 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
Subtitle of host publication | Smarter Technology for a Healthier World, EMBC 2017 - Proceedings |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 3576-3579 |
Number of pages | 4 |
ISBN (Electronic) | 9781509028092 |
DOIs | |
State | Published - Sep 13 2017 |
Event | 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, Korea, Republic of Duration: Jul 11 2017 → Jul 15 2017 |
Publication series
Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
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ISSN (Print) | 1557-170X |
Other
Other | 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 |
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Country/Territory | Korea, Republic of |
City | Jeju Island |
Period | 7/11/17 → 7/15/17 |
Funding
*Research supported by the National Institutes of Health. This work was supported by the Harvard Catalyst and NIH grants R43MH107037 and K99EB021320,.
ASJC Scopus subject areas
- Signal Processing
- Health Informatics
- Computer Vision and Pattern Recognition
- Biomedical Engineering