Embryonic and adult expression patterns of the Tec tyrosine kinase gene suggest a role in megakaryocytopoiesis, blood vessel development, and melanogenesis

Michael Klüppel, Dorit B. Donoviel, Mary E. Brunkow, Benny Motro, Alan Bernstein*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The Tec cytoplasmic tyrosine kinase is a member of a family of src-like proteins that are thought to play important roles in hematopoiesis. Here we describe the temporal and spatial expression of the Tec gene during embryogenesis and in the adult. Our data demonstrate that embryonic Tec expression is restricted to distinct hematopoietic cells as well as structures and cell types that share a common feature of containing fluid in an enclosed cavity, e.g., endothelial cells. In addition, Tec is expressed in melanocytes late in gestation. The observed developmental expression pattern of Tec suggests a role for this gene in several aspects of hematopoiesis and/or blood vessel development as well as in late stages of melanogenesis.

Original languageEnglish (US)
Pages (from-to)1249-1256
Number of pages8
JournalCell Growth and Differentiation
Volume8
Issue number12
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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