TY - JOUR
T1 - Emergency administration of radiocontrast media in high-risk patients
AU - Greenberger, Paul A.
AU - Michael Halwig, J.
AU - Patterson, Roy
AU - Wallemark, Carl B.
N1 - Funding Information:
From the Section of Allergy-Immunology, Department of Medicine, and the Biometry Section of the Cancer Center, Northwestern University Medical School, Chicago, Ill. Supported by United States Public Health Service Grant AI-11403 and the Emest S. Bazley Trust. Received for publication Jan. 30, 1985. Accepted for publication Sept. 12, 1985. Reprintr equests: Paul A. Greenberger, M.D., Notthwestem Uni-versity Medical School, 303 E. Chicago Ave., Chicago, IL 60611.
PY - 1986/4
Y1 - 1986/4
N2 - Patients with previous anaphylactoid reactions to radiographic contrast media (RCM) are at increased risk for subsequent reactions on repeat exposure. The most efficacious pretreatment regimens require administration of medications up to 13 hours before the anticipated procedure. Emergency administration of RCM in patients requiring essential procedures precludes prolonged pretreatment. We report results of pretreatment in nine patients requiring emergency administration of RCM. We recommend hydrocortisone, 200 mg intravenously, immediately, and every 4 hours until the procedure is completed, and diphenhydramine, 50 mg intravenously, 1 hour before the procedure. No reactions occurred in these patients, suggesting that this pretreatment regimen may be valuable in prophylaxis for patients requiring emergency administration of RCM who have experienced previous anaphylactoid reactions. Although used in only one additional patient, ephedrine, 25 mg orally, 1 hour before the procedure may also be valuable.
AB - Patients with previous anaphylactoid reactions to radiographic contrast media (RCM) are at increased risk for subsequent reactions on repeat exposure. The most efficacious pretreatment regimens require administration of medications up to 13 hours before the anticipated procedure. Emergency administration of RCM in patients requiring essential procedures precludes prolonged pretreatment. We report results of pretreatment in nine patients requiring emergency administration of RCM. We recommend hydrocortisone, 200 mg intravenously, immediately, and every 4 hours until the procedure is completed, and diphenhydramine, 50 mg intravenously, 1 hour before the procedure. No reactions occurred in these patients, suggesting that this pretreatment regimen may be valuable in prophylaxis for patients requiring emergency administration of RCM who have experienced previous anaphylactoid reactions. Although used in only one additional patient, ephedrine, 25 mg orally, 1 hour before the procedure may also be valuable.
UR - http://www.scopus.com/inward/record.url?scp=0022606921&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022606921&partnerID=8YFLogxK
U2 - 10.1016/0091-6749(86)90357-X
DO - 10.1016/0091-6749(86)90357-X
M3 - Article
C2 - 3958391
AN - SCOPUS:0022606921
VL - 77
SP - 630
EP - 634
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 4
ER -