Emerging biomarkers in personalized therapy of lung cancer

Philip T. Cagle*, Kirtee Raparia, Bryce P. Portier

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

The two clinically validated and Food and Drug Administration approved lung cancer predictive biomarkers (epidermal growth factor receptor mutations and anaplastic lymphoma kinase (ALK) translocations) occur in only about 20 % of lung adenocarcinomas and acquired resistance develops to fi rst generation drugs. Several other oncogenic drivers for lung adenocarcinoma have emerged as potentially druggable targets with new predictive biomarkers. Oncologists are requesting testing for ROS 1 translocations which predict susceptibility to crizotinib, already approved for ALK positive lung cancers. Other potential biomarkers which are currently undergoing clinical trials are RET, MET, HER2 and BRAF. Detection of these biomarkers includes fl uorescent in situ hybridization and/or reverse transcriptase polymerase chain reaction (ROS1, RET, HER2), mutation analysis (BRAF) and immunohistochemistry (MET). Screening by immunohistochemistry may be useful for some biomarkers (ROS1, BRAF). Targeted next generation sequencing techniques may be useful as well. These fi ve biomarkers are under consideration for inclusion in revised lung cancer biomarker guidelines by the College of American Pathologists, International Association for the Study of Lung Cancer and Association for Molecular Pathology.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages25-36
Number of pages12
DOIs
StatePublished - Oct 1 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume890
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • BRAF
  • Crizotinib
  • Fluorescent in situ hybridization
  • HER2
  • Immunohistochemistry
  • MET
  • Multikinase inhibitors
  • RET
  • ROS1
  • Reverse transcriptase polymerase chain reaction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Cagle, P. T., Raparia, K., & Portier, B. P. (2016). Emerging biomarkers in personalized therapy of lung cancer. In Advances in Experimental Medicine and Biology (pp. 25-36). (Advances in Experimental Medicine and Biology; Vol. 890). Springer New York LLC. https://doi.org/10.1007/978-3-319-24932-2_2