Emerging clinical concerns in the ageing haemophilia patient

B. A. Konkle*, C. Kessler, L. Aledort, J. Andersen, P. Fogarty, P. Kouides, D. Quon, M. Ragni, A. Zakarija, B. Ewenstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


The availability of safe replacement clotting factor concentrates together with effective antiviral drugs to treat human immunodeficiency and hepatitis C viruses and the provision of care at designated haemophilia treatment centres have resulted in a new phenomenon in haemophilia management - the ageing patient. Today, increasing numbers of persons with haemophilia (PWH) are middle-aged and older, and they face the same age-related health issues as the general population. The impact of these risks on PWH is unclear, however, and there is a paucity of information about how to manage comorbidities in this patient population. This review focuses on five comorbidities that uniquely affect older PWH: cardiovascular disease, liver disease, cancer, renal disease and joint disease. Available research is summarized and potential management approaches are suggested.

Original languageEnglish (US)
Pages (from-to)1197-1209
Number of pages13
Issue number6
StatePublished - Nov 2009


  • Ageing
  • Comorbidities
  • Haemophilia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Hematology


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