Emerging Food Allergy Biomarkers

Sarita U. Patil*, Supinda Bunyavanich, M. Cecilia Berin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The management of food allergy is complicated by the lack of highly predictive biomarkers for diagnosis and prediction of disease course. The measurement of food-specific IgE is a useful tool together with clinical history but is an imprecise predictor of clinical reactivity. The gold standard for diagnosis and clinical research is a double-blind placebo-controlled food challenge. Improvement in our understanding of immune mechanisms of disease, development of high-throughput technologies, and advances in bioinformatics have yielded a number of promising new biomarkers of food allergy. In this review, we will discuss advances in immunoglobulin measurements, the utility of the basophil activation test, T-cell profiling, and the use of -omic technologies (transcriptome, epigenome, microbiome, and metabolome) as biomarker tools in food allergy.

Original languageEnglish (US)
Pages (from-to)2516-2524
Number of pages9
JournalJournal of Allergy and Clinical Immunology: In Practice
Issue number8
StatePublished - Sep 2020


  • Basophil activation test
  • Biomarker
  • Components
  • Double-blind placebo-controlled food challenge (DBPCFC)
  • Epigenome
  • Epitopes
  • Metabolome
  • Microbiome
  • T-cell receptor repertoire
  • Transcriptome

ASJC Scopus subject areas

  • Immunology and Allergy


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