Emerging functional similarities and divergences between Drosophila Spargel/dPGC-1 and mammalian PGC-1 protein

Subhas Mukherjee, Mohammed A. Basar, Claudette Davis, Atanu Duttaroy*

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Peroxisome Proliferator Activated Receptor Gamma Co-activator-1 (PGC-1) is a well-conserved protein among all chordates. Entire Drosophila species subgroup carries a PGC-1 homolog in their genome called spargel/dPGC-1 showing very little divergence. Recent studies have reported that significant functional similarities are shared between vertebrate and invertebrate PGC-1's based on their role in mitochondrial functions and biogenesis, gluconeogenesis, and most likely in transcription and RNA processing. With the help of genetic epistasis analysis, we established that Drosophila Spargel/dPGC-1 affects cell growth process as a terminal effector in the Insulin-TOR signaling pathway. The association between Spargel/dPGC-1 and Insulin signaling could also explain its role in the aging process. Here we provided a further comparison between Spargel/dPGC-1 and PGC-1 focusing on nuclear localization, oxidative stress resistance, and a possible role of Spargel/dPGC-1 in oogenesis reminiscing the role of Spargel in reproductive aging like many Insulin signaling partners. This led us to hypothesize that the discovery of newer biological functions in Drosophila Spargel/dPGC-1 will pave the way to uncover novel functional equivalents in mammals.

Original languageEnglish (US)
Article numberArticle 216
JournalFrontiers in Genetics
Volume5
Issue numberJUL
DOIs
StatePublished - Jan 1 2014

Keywords

  • Drosophila
  • Mitochondria
  • Oogenesis
  • PGC-1
  • RNA processing

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

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