Emerging functions of force-producing kinetochore motors

Yinghui Mao, Dileep Varma, Richard Vallee*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

More than two decades of research has resulted in the identification of some 60 microtubule motor proteins, several of which have been implicated in mitosis. Although some kinesin superfamily proteins function as microtubule depolymerases at kinetochores, such as Kinesin-8 and -13, it is now appreciated that there are only two force-producing kinetochore associated motors, the plus end-directed microtubule motor CENP-E and the minus end-directed microtubule motor cytoplasmic dynein. Defining their roles at kinetochores has been hampered by the complexity of mitosis itself, and a multiplicity of mitotic roles, at least for cytoplasmic dynein. Nonetheless, recent advances have served to define the primary roles of the two kinetochore motors in detail.

Original languageEnglish (US)
Pages (from-to)715-719
Number of pages5
JournalCell Cycle
Volume9
Issue number4
DOIs
StatePublished - Feb 15 2010

Keywords

  • CENP-E
  • Checkpoint
  • Dynein
  • Microtubule
  • Mitosis
  • Motor

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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