Emerging importance of ACE2 in external stratified epithelial tissues

Nihal Kaplan; Elena Gonzalez; Han Peng; Daniel Batlle; Robert M. Lavker

doi:10.1016/j.mce.2021.111260

Emerging importance of ACE2 in external stratified epithelial tissues

Nihal Kaplan, Elena Gonzalez, Han Peng^*, Daniel Batlle^*, Robert M. Lavker^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), has been identified as the receptor for the SARS-CoV-2. Several RAS components including ACE2 and its substrate Ang II are present in both eye and skin, two stratified squamous epithelial tissues that isolate organisms from external environment. Our recent findings in cornea and others in both skin and eye suggest contribution of this system, and specifically of ACE2 in variety of physiological and pathological responses of these organ systems. This review will focus on the role RAS system plays in both skin and cornea, and will specifically discuss our recent findings on ACE2 in corneal epithelial inflammation, as well as potential implications of ACE2 in patients with COVID-19.

Original language	English (US)
Article number	111260
Journal	Molecular and Cellular Endocrinology
Volume	529
DOIs	https://doi.org/10.1016/j.mce.2021.111260
State	Published - Jun 1 2021

Keywords

Corneal epithelium
Epidermis
Renin-angiotensin system (RAS)

ASJC Scopus subject areas

Endocrinology
Molecular Biology
Biochemistry

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10.1016/j.mce.2021.111260

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title = "Emerging importance of ACE2 in external stratified epithelial tissues",

abstract = "Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), has been identified as the receptor for the SARS-CoV-2. Several RAS components including ACE2 and its substrate Ang II are present in both eye and skin, two stratified squamous epithelial tissues that isolate organisms from external environment. Our recent findings in cornea and others in both skin and eye suggest contribution of this system, and specifically of ACE2 in variety of physiological and pathological responses of these organ systems. This review will focus on the role RAS system plays in both skin and cornea, and will specifically discuss our recent findings on ACE2 in corneal epithelial inflammation, as well as potential implications of ACE2 in patients with COVID-19.",

keywords = "Corneal epithelium, Epidermis, Renin-angiotensin system (RAS)",

author = "Nihal Kaplan and Elena Gonzalez and Han Peng and Daniel Batlle and Lavker, {Robert M.}",

note = "Funding Information: This research is supported by National Institutes of Health Grants EY028560 and EY019463 (to R.M.L.); a Dermatology Foundation research grant and Career Development Award (to H.P.); an Eversight research grant (to H.P.), an NIDDK grant R01DK104785 (to D.B.). Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

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doi = "10.1016/j.mce.2021.111260",

language = "English (US)",

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journal = "Molecular and Cellular Endocrinology",

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T1 - Emerging importance of ACE2 in external stratified epithelial tissues

AU - Kaplan, Nihal

AU - Gonzalez, Elena

AU - Peng, Han

AU - Batlle, Daniel

AU - Lavker, Robert M.

N1 - Funding Information: This research is supported by National Institutes of Health Grants EY028560 and EY019463 (to R.M.L.); a Dermatology Foundation research grant and Career Development Award (to H.P.); an Eversight research grant (to H.P.), an NIDDK grant R01DK104785 (to D.B.). Publisher Copyright: © 2021 Elsevier B.V.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), has been identified as the receptor for the SARS-CoV-2. Several RAS components including ACE2 and its substrate Ang II are present in both eye and skin, two stratified squamous epithelial tissues that isolate organisms from external environment. Our recent findings in cornea and others in both skin and eye suggest contribution of this system, and specifically of ACE2 in variety of physiological and pathological responses of these organ systems. This review will focus on the role RAS system plays in both skin and cornea, and will specifically discuss our recent findings on ACE2 in corneal epithelial inflammation, as well as potential implications of ACE2 in patients with COVID-19.

AB - Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), has been identified as the receptor for the SARS-CoV-2. Several RAS components including ACE2 and its substrate Ang II are present in both eye and skin, two stratified squamous epithelial tissues that isolate organisms from external environment. Our recent findings in cornea and others in both skin and eye suggest contribution of this system, and specifically of ACE2 in variety of physiological and pathological responses of these organ systems. This review will focus on the role RAS system plays in both skin and cornea, and will specifically discuss our recent findings on ACE2 in corneal epithelial inflammation, as well as potential implications of ACE2 in patients with COVID-19.

KW - Corneal epithelium

KW - Epidermis

KW - Renin-angiotensin system (RAS)

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DO - 10.1016/j.mce.2021.111260

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AN - SCOPUS:85103737621

SN - 0303-7207

VL - 529

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

M1 - 111260

ER -

Emerging importance of ACE2 in external stratified epithelial tissues

Abstract

Keywords

ASJC Scopus subject areas

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