Emerging Roles for Dendritic Cells in Heart Failure

Danish Saleh*, Rebecca T.L. Jones, Samantha L. Schroth, Edward B. Thorp, Matthew J. Feinstein

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The field of cardio-immunology has emerged from discoveries that define roles for innate and adaptive immune responses associated with myocardial inflammation and heart failure. Dendritic cells (DCs) comprise an important cellular compartment that contributes to systemic immune surveillance at the junction of innate and adaptive immunity. Once described as a singular immune subset, we now appreciate that DCs consist of a heterogeneous pool of subpopulations, each with distinct effector functions that can uniquely regulate the acute and chronic inflammatory response. Nevertheless, the cardiovascular-specific context involving DCs in negotiating the biological response to myocardial injury is not well understood. Herein, we review our current understanding of the role of DCs in cardiac inflammation and heart failure, including gaps in knowledge and clinical relevance.

Original languageEnglish (US)
Article number1535
JournalBiomolecules
Volume13
Issue number10
DOIs
StatePublished - Oct 2023

Keywords

  • T cells
  • cardio-immunology
  • dendritic cells
  • dilated cardiomyopathy
  • heart failure
  • heart-failure with preserved ejection fraction (HFpEF)
  • hypertensive heart disease
  • ischemic cardiomyopathy
  • myocardial inflammation
  • myocarditis

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry

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