Emerging roles of lysine methylation on non-histone proteins

Xi Zhang, Yaling Huang, Xiaobing Shi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations


Lysine methylation is a common posttranslational modification (PTM) of histones that is important for the epigenetic regulation of transcription and chromatin in eukaryotes. Increasing evidence demonstrates that in addition to histones, lysine methylation also occurs on various non-histone proteins, especially transcription- and chromatin-regulating proteins. In this review, we will briefly describe the histone lysine methyltransferases (KMTs) that have a broad spectrum of non-histone substrates. We will use p53 and nuclear receptors, especially estrogen receptor alpha, as examples to discuss the dynamic nature of non-histone protein lysine methylation, the writers, erasers, and readers of these modifications, and the crosstalk between lysine methylation and other PTMs in regulating the functions of the modified proteins. Understanding the roles of lysine methylation in normal cells and during development will shed light on the complex biology of diseases associated with the dysregulation of lysine methylation on both histones and non-histone proteins.

Original languageEnglish (US)
Pages (from-to)4257-4272
Number of pages16
JournalCellular and Molecular Life Sciences
Issue number22
StatePublished - Nov 1 2015


  • ERα
  • G9a
  • Lysine methylation
  • SETD7
  • SMYD2
  • p53

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Medicine
  • Molecular Biology
  • Cell Biology
  • Pharmacology


Dive into the research topics of 'Emerging roles of lysine methylation on non-histone proteins'. Together they form a unique fingerprint.

Cite this