Emerging Targets for the Management of Osteoarthritis Pain

Anne Marie Malfait*, Richard J. Miller

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Worldwide, osteoarthritis (OA) is one of the leading causes of chronic pain, for which adequate relief is not available. Ongoing peripheral input from the affected joint is a major factor in OA-associated pain. Therefore, this review focuses predominantly on peripheral targets emerging in the preclinical and clinical arena. Nerve growth factor is the most advanced of these targets, and its blockade has shown tremendous promise in clinical trials in knee OA. A number of different types of ion channels, including voltage-gated sodium channels and calcium channels, transient receptor potential channels, and acid-sensing ion channels, are important for neuronal excitability and play a role in pain genesis. Few channel blockers have been tested in preclinical models of OA, with varying results. Finally, we discuss some examples of G-protein coupled receptors, which may offer attractive therapeutic strategies for OA pain, including receptors for bradykinin, calcitonin gene-related peptide, and chemokines. Since many of the pathways described above can be selectively and potently targeted, they offer an exciting opportunity for pain management in OA, either systemically or locally.

Original languageEnglish (US)
Pages (from-to)260-268
Number of pages9
JournalCurrent Osteoporosis Reports
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2016

Keywords

  • GPCRs
  • Ion channels
  • Nerve growth factor
  • Osteoarthritis
  • Pain
  • Targets

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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