Emotional reactivity following surgery to the prefrontal cortex

Lisanne M. Jenkins*, David G. Andrewes, Christian L. Nicholas, Katharine J. Drummond, Bradford A. Moffat, Pramit M. Phal, Patricia Desmond

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We aimed to elicit emotion in patients with surgically circumscribed lesions of the prefrontal cortex (PFC) in order to elucidate the precise functional roles in emotion processing of the discrete subregions comprising the ventromedial PFC, including the medial PFC and orbitofrontal cortex (OFC). Three components of emotional reactivity were measured: subjective experience, behaviour, and physiological response. These included measures of self-reported emotion, observer-rated facial expression of emotion and measurements of heart rate and heart rate variability (HRV) during film viewing, and a measure of subjective emotional change since surgery. Patients with lesions to the ventromedial PFC demonstrated significant differences compared with controls in HRV during the film clips, suggesting a shift to greater dominance of sympathetic input. In contrast, patients with lesions restricted to the OFC showed significant differences in HRV suggesting reduced sympathetic input. They also showed less facial expression of emotion during positive film clips, and reported more subjective emotional change since surgery compared with controls. This human lesion study is important for refining theoretical models of emotion processing by the ventromedial PFC, which until now have primarily been based on anatomical connectivity, animal lesion, and human functional neuroimaging research. Such theories have implications for the treatment of a wide variety of emotional disorders.

Original languageEnglish (US)
Pages (from-to)120-141
Number of pages22
JournalJournal of Neuropsychology
Volume12
Issue number1
DOIs
StatePublished - Mar 2018
Externally publishedYes

Keywords

  • Emotion
  • orbitofrontal cortex
  • prefrontal cortex
  • ventromedial

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Fingerprint

Dive into the research topics of 'Emotional reactivity following surgery to the prefrontal cortex'. Together they form a unique fingerprint.

Cite this