Emphasizing statin safety in the hospitalized patient: A review

Alicia Leung, Eric W. Schaefer, Michael W. Tempelhof, Neil J. Stone*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


This review examines the safe use of statin therapy in the hospitalized patient. Available data support initiation of statin therapy during hospitalization in patients with acute coronary syndromes or established cardiovascular disease and in high-risk patients with diabetes mellitus and chronic kidney disease (except for those on maintenance hemodialysis). Because of the increased risk of cardiovascular disease, statins are given to solid-organ transplant survivors and those treated with protease inhibitors for human immunodeficiency virus. However, in the multidrug, acute illness hospital environment, safety considerations become paramount. We review the essentials of statin metabolism and drug-drug interactions to provide the hospital physician with information to minimize potentially serious adverse statin effects.

Original languageEnglish (US)
Pages (from-to)845-853
Number of pages9
JournalAmerican Journal of Medicine
Issue number9
StatePublished - Sep 2012


  • Hepatotoxicity
  • Myotoxicity
  • Nephrotoxicity
  • Statin safety

ASJC Scopus subject areas

  • Medicine(all)


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