Enabling tetracationic cyclophane production by trading templates

Chi Hau Sue, Subhadeep Basu, Albert C. Fahrenbach, Alexander K. Shveyd, Sanjeev K. Dey, Youssry Y. Botros, J. Fraser Stoddart

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

The time taken to produce the ubiquitous and promiscuous receptor, which has become known as the little "blue box", has been halved as a result of using a pH-responsive derivative of 1,5-diaminonaphthalene to displace the template employed during its synthesis. The fact that this surrogate trades places within the cavity of the "blue box" is the key to the time-saving for the simple reason that it leaves the lock, so-to-speak, as soon as it becomes protonated by a strong acid. During the subsequent full characterisation of the "blue box", it was discovered that the tetracationic cyclophane exists at least in two different polymorphs in the solid state.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalChemical Science
Volume1
Issue number1
DOIs
StatePublished - Jul 2010

ASJC Scopus subject areas

  • Chemistry(all)

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