Abstract
An improved three-step synthesis has been developed for the preparation of N-docosanoyl-D-valine tert.-butylamide. This gas chromatographic phase, and the corresponding previously described enantiomeric L-valine phase, which bring about a reversal in the elution patterns of antipodes, were found to perform with comparable accuracy and precision when used for the gas chromatographic analysis of D- and L-leucine mixtures. This reversal of the elution pattern of enantiomeric eluates offers a number of hitherto unattainable advantages in both qualitative and quantitative gas chromatographic analyses of enantiomer mixtures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 153-159 |
| Number of pages | 7 |
| Journal | Journal of Chromatography A |
| Volume | 169 |
| Issue number | C |
| DOIs | |
| State | Published - Feb 1 1979 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Organic Chemistry
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Enantiomeric phases in analytical gas chromatography. / Bonner, William A.; Blair, Neal E.
In: Journal of Chromatography A, Vol. 169, No. C, 01.02.1979, p. 153-159.Research output: Contribution to journal › Article
TY - JOUR
T1 - Enantiomeric phases in analytical gas chromatography
AU - Bonner, William A.
AU - Blair, Neal E.
PY - 1979/2/1
Y1 - 1979/2/1
N2 - An improved three-step synthesis has been developed for the preparation of N-docosanoyl-D-valine tert.-butylamide. This gas chromatographic phase, and the corresponding previously described enantiomeric L-valine phase, which bring about a reversal in the elution patterns of antipodes, were found to perform with comparable accuracy and precision when used for the gas chromatographic analysis of D- and L-leucine mixtures. This reversal of the elution pattern of enantiomeric eluates offers a number of hitherto unattainable advantages in both qualitative and quantitative gas chromatographic analyses of enantiomer mixtures.
AB - An improved three-step synthesis has been developed for the preparation of N-docosanoyl-D-valine tert.-butylamide. This gas chromatographic phase, and the corresponding previously described enantiomeric L-valine phase, which bring about a reversal in the elution patterns of antipodes, were found to perform with comparable accuracy and precision when used for the gas chromatographic analysis of D- and L-leucine mixtures. This reversal of the elution pattern of enantiomeric eluates offers a number of hitherto unattainable advantages in both qualitative and quantitative gas chromatographic analyses of enantiomer mixtures.
UR - http://www.scopus.com/inward/record.url?scp=0006601369&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0006601369&partnerID=8YFLogxK
U2 - 10.1016/0021-9673(75)85040-0
DO - 10.1016/0021-9673(75)85040-0
M3 - Article
VL - 169
SP - 153
EP - 159
JO - Journal of Chromatography A
JF - Journal of Chromatography A
SN - 0021-9673
IS - C
ER -