TY - JOUR
T1 - Enantiomeric phases in analytical gas chromatography
AU - Bonner, William A.
AU - Blair, Neal E.
N1 - Funding Information:
We are indebted to Dr. E. Gil-Av of the Weizmann Institute of Science, Rehovot, Israel for supplying us with the N-docosanoyl-L-valine @it_-butylamide phase used in the above studies, and to the National Aeronautics and Space Administration for a research grant (NGR-05-020-582) which supported this investigation.
PY - 1979/2/1
Y1 - 1979/2/1
N2 - An improved three-step synthesis has been developed for the preparation of N-docosanoyl-D-valine tert.-butylamide. This gas chromatographic phase, and the corresponding previously described enantiomeric L-valine phase, which bring about a reversal in the elution patterns of antipodes, were found to perform with comparable accuracy and precision when used for the gas chromatographic analysis of D- and L-leucine mixtures. This reversal of the elution pattern of enantiomeric eluates offers a number of hitherto unattainable advantages in both qualitative and quantitative gas chromatographic analyses of enantiomer mixtures.
AB - An improved three-step synthesis has been developed for the preparation of N-docosanoyl-D-valine tert.-butylamide. This gas chromatographic phase, and the corresponding previously described enantiomeric L-valine phase, which bring about a reversal in the elution patterns of antipodes, were found to perform with comparable accuracy and precision when used for the gas chromatographic analysis of D- and L-leucine mixtures. This reversal of the elution pattern of enantiomeric eluates offers a number of hitherto unattainable advantages in both qualitative and quantitative gas chromatographic analyses of enantiomer mixtures.
UR - http://www.scopus.com/inward/record.url?scp=0006601369&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0006601369&partnerID=8YFLogxK
U2 - 10.1016/0021-9673(75)85040-0
DO - 10.1016/0021-9673(75)85040-0
M3 - Article
AN - SCOPUS:0006601369
VL - 169
SP - 153
EP - 159
JO - Journal of Chromatography A
JF - Journal of Chromatography A
SN - 0021-9673
IS - C
ER -