Enantiomeric phases in analytical gas chromatography

An improved three-step synthesis has been developed for the preparation of N-docosanoyl-D-valine tert.-butylamide. This gas chromatographic phase, and the corresponding previously described enantiomeric L-valine phase, which bring about a reversal in the elution patterns of antipodes, were found to perform with comparable accuracy and precision when used for the gas chromatographic analysis of D- and L-leucine mixtures. This reversal of the elution pattern of enantiomeric eluates offers a number of hitherto unattainable advantages in both qualitative and quantitative gas chromatographic analyses of enantiomer mixtures.