Enantioselective β-Protonation by a Cooperative Catalysis Strategy

Michael H. Wang, Daniel T. Cohen, C. Benjamin Schwamb, Rama K Mishra, Karl A Scheidt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


An enantioselective N-heterocyclic carbene (NHC)-catalyzed β-protonation through the orchestration of three distinct organocatalysts has been developed. This cooperative catalyst system enhances both yield and selectivity, compared to only the NHC-catalyzed process. This new method allows for the efficient conversion of a large scope of aryl-oxobutenoates to highly enantioenriched succinate derivatives and demonstrates the benefits of combining different activation modes in organocatalysis.

Original languageEnglish (US)
Pages (from-to)5891-5894
Number of pages4
JournalJournal of the American Chemical Society
Issue number18
StatePublished - May 13 2015

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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