A convergent, catalytic asymmetric formal [4 + 2] annulation for the synthesis of dihydroquinolones has been developed. Carboxylic acids can be employed as precursors to NHC enolates through an in situ activation strategy. Simultaneous generation of a reactive aza-o-quinone methide under the basic conditions employed for NHC generation leads to a dual activation approach.
ASJC Scopus subject areas
- Colloid and Surface Chemistry
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Lee, A. (Creator), Younai, A. (Creator), Price, C. K. (Creator), Izquierdo, J. (Creator), Mishra, R. K. (Creator) & Scheidt, K. A. (Creator), Cambridge Crystallographic Data Centre, 2014