Enantioselective annulations for dihydroquinolones by in situ generation of azolium enolates

Anna Lee, Ashkaan Younai, Christopher K. Price, Javier Izquierdo, Rama K. Mishra, Karl A. Scheidt*

*Corresponding author for this work

Research output: Contribution to journalArticle

156 Scopus citations

Abstract

A convergent, catalytic asymmetric formal [4 + 2] annulation for the synthesis of dihydroquinolones has been developed. Carboxylic acids can be employed as precursors to NHC enolates through an in situ activation strategy. Simultaneous generation of a reactive aza-o-quinone methide under the basic conditions employed for NHC generation leads to a dual activation approach.

Original languageEnglish (US)
Pages (from-to)10589-10592
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number30
DOIs
StatePublished - Jul 30 2014

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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