Abstract
A highly enantioselective Friedel-Crafts alkylation of electron-rich aromatic nucleophiles catalyzed by scandium(III) triflate-pyridyl(bis)oxazoline complexes has been accomplished. The reaction involves α,β-unsaturated acyl phosphonates as electrophiles and primarily substituted indoles as nucleophiles. The reactive acyl phosphonate product is converted to the corresponding ester or amide in good overall yield by adding an alcohol or amine directly to the reaction mixture.
Original language | English (US) |
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Pages (from-to) | 10780-10781 |
Number of pages | 2 |
Journal | Journal of the American Chemical Society |
Volume | 125 |
Issue number | 36 |
DOIs | |
State | Published - Sep 10 2003 |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
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CCDC 232264: Experimental Crystal Structure Determination
Evans, D. A. (Creator), Scheidt, K. A. (Creator), Fandrick, K. R. (Creator), Lam, H. W. (Creator) & Wu, J. (Creator), Cambridge Crystallographic Data Centre, 2004
DOI: 10.5517/cc7spd2, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc7spd2&sid=DataCite
Dataset
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CCDC 232265: Experimental Crystal Structure Determination
Evans, D. A. (Creator), Scheidt, K. A. (Creator), Fandrick, K. R. (Creator), Lam, H. W. (Creator) & Wu, J. (Creator), Cambridge Crystallographic Data Centre, 2004
DOI: 10.5517/cc7spf3, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc7spf3&sid=DataCite
Dataset