Abstract
Methods for generating substituted imidazoles
NU 2013-003
Inventors
Karl A. Scheidt*
Elizabeth A. O'Bryan
Short Description
Improved method for producing substituted imidazoles, key biologically active compounds used against a variety of diseases
Abstract
Substituted imidazoles are a privileged structural motif present in small molecules active against HIV, depression and inflammation. Methods for producing these types of molecules are rarely reported, indicating there is a high degree of difficulty involved in these processes. Northwestern University researchers have developed a novel method for producing substituted imidazoles with various functional groups. Their method is simple, efficient and can be used with a variety of functional groups to produce a large variety of compounds. Furthermore, this method can be applied to synthesizing novel amino acids by introducing new functional groups onto a glutamic acid scaffold. This novel class of compounds is expected to have a huge variety of biological functions and find many applications in the field of drug development.
Applications
o Anti-inflammatory, anti-depressant, anti-viral drugs
o New amino acid derivatives
Advantages
o Operationally simple reaction
o High yield with excellent enantioselectivity
o Large number (over 15) of functional groups is tolerated
Publications
McCusker O'Bryan E, Scheidt KA. Enantioselective N-Heterocyclin Carbene Catalyzed Annulation Reactions with Imidazolidinones (2013). Angew. Chem. Int. Ed. 52: 13616-13620.
IP Status
Issued US patent 8,912, 341.
Marketing Contact
Allan Nader, PhD
Invention Manager
(e) [email protected]
(p) 847.491.4456
Tags
CHEMICAL: methods, CHEMICAL: medicinal
Original language | English |
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Patent number | 8912341 |
State | Published - Jul 24 2014 |