Enantioselective N-heterocyclic carbene catalyzed annulation reactions with imidazolidinones

Elizabeth O.Bryan McCusker, Karl A. Scheidt

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Add acetic acid: A highly stereoselective N-heterocyclic carbene (NHC)-catalyzed formal [4+2] annulation between α,β-unsaturated aldehydes and imidazolidinones for the synthesis of imidazoles has been developed. Acetic acid serves as a key additive to achieve high chemoselectivity for the formal [4+2] annulation product.

Original languageEnglish (US)
Pages (from-to)13616-13620
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number51
StatePublished - Dec 16 2013


  • N-heterocyclic carbenes
  • asymmetric synthesis
  • catalysis
  • enals
  • organocatalysis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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