Abstract
Add acetic acid: A highly stereoselective N-heterocyclic carbene (NHC)-catalyzed formal [4+2] annulation between α,β-unsaturated aldehydes and imidazolidinones for the synthesis of imidazoles has been developed. Acetic acid serves as a key additive to achieve high chemoselectivity for the formal [4+2] annulation product.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 13616-13620 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 51 |
| DOIs | |
| State | Published - Dec 16 2013 |
Keywords
- N-heterocyclic carbenes
- asymmetric synthesis
- catalysis
- enals
- organocatalysis
ASJC Scopus subject areas
- General Chemistry
- Catalysis
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CCDC 956375: Experimental Crystal Structure Determination
McCusker, E. O. (Creator) & Scheidt, K. A. (Creator), Cambridge Crystallographic Data Centre, 2014
DOI: 10.5517/cc1135t4, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc1135t4&sid=DataCite
Dataset
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CCDC 956376: Experimental Crystal Structure Determination
McCusker, E. O. (Creator) & Scheidt, K. A. (Creator), Cambridge Crystallographic Data Centre, 2014
DOI: 10.5517/cc1135v5, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc1135v5&sid=DataCite
Dataset