Enantioselective organocatalytic mannich reactions with autocatalysts and their mimics

Xinbo Wang, Yongbo Zhang, Haibo Tan, Yanchao Wang, Peng Han, David Zhigang Wang

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

(Figure Presented) The Mannich reactions previously extensively investigated with organocatalysis of L-proline and other related small molecules were reinvestigated with detailed stereochemical analysis of their autocatalysis pathways, through employment of both the products themselves and their close structural mimics as the catalysts. These organo-autocatalytic processes function as meaningful molecular models toward understanding the origin and maintenance of homochirality under biologically relevant conditions.

Original languageEnglish (US)
Pages (from-to)2403-2406
Number of pages4
JournalJournal of Organic Chemistry
Volume75
Issue number7
DOIs
StatePublished - Apr 2 2010

ASJC Scopus subject areas

  • Organic Chemistry

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