Enantioselective reductions of aromatic ketones with ammonia-borane complexes of chiral tetraphenyl-18-crown-6 derivatives

Billy L. Allwood*, Hooshang Shahriari-Zavareh, J. Fraser Stoddart, David J. Williams

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Enantioselective reductions of prochiral aromatic ketones with adducts formed between ammonia-borane and (2R,3R,11R,12R)- and (2S,3S,11S,12S)- tetraphenyl-1,4,7,10,13,16-hexaoxacyclo-octadecane, (RRRR)-(3) and (SSSS)-(3), have afforded the corresponding (S) and (R) aromatic secondary alcohols with enantiomeric excesses of 20-67%.

Original languageEnglish (US)
Pages (from-to)1461-1464
Number of pages4
JournalJournal of the Chemical Society, Chemical Communications
Issue number22
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Molecular Medicine

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