Enantioselective total synthesis and confirmation of the absolute and relative stereochemistry of streptorubin B

Dennis X. Hu, Michael D. Clift, Kiel E. Lazarski, Regan J. Thomson

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

The enantioselective total synthesis of the pyrrolophane natural product streptorubin B is described. Key steps in the concise route include the application of a one-pot enantioselective aldol cyclization/Wittig reaction and an anionic oxy-Cope rearrangement to forge the crucial 10-membered ring. Comparisons between CD spectra of synthetic and natural samples of streptorubin B coupled with X-ray crystallography allowed for the determination of the absolute stereochemistry of this natural product for the first time. These studies also provided unambiguous proof of the relative configuration between the butyl side chain and the bispyrrole subunit. Additional studies revealed a novel atropstereoselective Paal-Knorr pyrrole condensation and provided fundamental experimental insight into the barrier for atropisomerization of the natural product.

Original languageEnglish (US)
Pages (from-to)1799-1804
Number of pages6
JournalJournal of the American Chemical Society
Volume133
Issue number6
DOIs
StatePublished - Feb 16 2011

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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