TY - JOUR
T1 - Encoding of sequence and boundaries of scripts following prefrontal lesions
AU - Sirigu, Angela
AU - Zalla, Tiziana
AU - Pillon, Bernard
AU - Grafman, Jordan
AU - Agid, Yves
AU - Dubois, Bruno
N1 - Funding Information:
Acknowledgements. This research was supported by the EC Human Capital and Mobility fellowship to the first author.
PY - 1996/6
Y1 - 1996/6
N2 - Script analysis was investigated in patients with lesions in the prefrontal (n = 10) and posterior (n = 8) cortical regions, and in normal subjects (n = 15). The selection and temporal organization of relevant actions belonging to different pre-established sequences were studied in three different situations: (A) script with headers, (B) script with headers and distracters, and (C) scripts without headers. Contrarily to Normals and Posterior patients, Frontal patients committed sequence and boundary errors, and failed to eliminate distracters elements. The analysis of errors suggests two different cognitive modes of representing actions: (1) One using temporal contiguity between actions, that would be mainly under the control of the posterior associative areas; (2) the other, using the goal of the action and its consequences as a binding element between script and context, that would require the intervention of prefrontal cortex.
AB - Script analysis was investigated in patients with lesions in the prefrontal (n = 10) and posterior (n = 8) cortical regions, and in normal subjects (n = 15). The selection and temporal organization of relevant actions belonging to different pre-established sequences were studied in three different situations: (A) script with headers, (B) script with headers and distracters, and (C) scripts without headers. Contrarily to Normals and Posterior patients, Frontal patients committed sequence and boundary errors, and failed to eliminate distracters elements. The analysis of errors suggests two different cognitive modes of representing actions: (1) One using temporal contiguity between actions, that would be mainly under the control of the posterior associative areas; (2) the other, using the goal of the action and its consequences as a binding element between script and context, that would require the intervention of prefrontal cortex.
UR - http://www.scopus.com/inward/record.url?scp=0029895689&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029895689&partnerID=8YFLogxK
U2 - 10.1016/S0010-9452(96)80052-9
DO - 10.1016/S0010-9452(96)80052-9
M3 - Article
C2 - 8800616
AN - SCOPUS:0029895689
SN - 0010-9452
VL - 32
SP - 297
EP - 310
JO - Cortex
JF - Cortex
IS - 2
ER -