Encoding of sequence and boundaries of scripts following prefrontal lesions

Angela Sirigu*, Tiziana Zalla, Bernard Pillon, Jordan Grafman, Yves Agid, Bruno Dubois

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

128 Scopus citations


Script analysis was investigated in patients with lesions in the prefrontal (n = 10) and posterior (n = 8) cortical regions, and in normal subjects (n = 15). The selection and temporal organization of relevant actions belonging to different pre-established sequences were studied in three different situations: (A) script with headers, (B) script with headers and distracters, and (C) scripts without headers. Contrarily to Normals and Posterior patients, Frontal patients committed sequence and boundary errors, and failed to eliminate distracters elements. The analysis of errors suggests two different cognitive modes of representing actions: (1) One using temporal contiguity between actions, that would be mainly under the control of the posterior associative areas; (2) the other, using the goal of the action and its consequences as a binding element between script and context, that would require the intervention of prefrontal cortex.

Original languageEnglish (US)
Pages (from-to)297-310
Number of pages14
Issue number2
StatePublished - Jun 1996

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience


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