End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis

Yolanda Stypula-Cyrus, Nikhil N. Mutyal, Mart Dela Cruz, Dhananjay P. Kunte, Andrew J. Radosevich, Ramesh Wali, Hemant K. Roy*, Vadim Backman

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

End-binding protein (EB1) is a microtubule protein that binds to the tumor suppressor adenomatous polyposis coli (APC). While EB1 is implicated as a potential oncogene, its role in cancer progression is unknown. Therefore, we analyzed EB1/APC expression at the earliest stages of colorectal carcinogenesis and in the uninvolved mucosa ("field effect") of human and animal tissue. We also performed siRNA-knockdown in colon cancer cell lines. EB1 is up-regulated in early and field carcinogenesis in the colon, and the cellular/nano-architectural effect of EB1 knockdown depended on the genetic context. Thus, dysregulation of EB1 is an important early event in colon carcinogenesis.

Original languageEnglish (US)
Pages (from-to)829-835
Number of pages7
JournalFEBS Letters
Volume588
Issue number5
DOIs
StatePublished - Mar 3 2014

Keywords

  • Adenomatous polyposis coli
  • Colon cancer
  • End-binding protein 1
  • Field carcinogenesis
  • Sub-diffractional structure

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Stypula-Cyrus, Y., Mutyal, N. N., Dela Cruz, M., Kunte, D. P., Radosevich, A. J., Wali, R., Roy, H. K., & Backman, V. (2014). End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis. FEBS Letters, 588(5), 829-835. https://doi.org/10.1016/j.febslet.2014.01.046