Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue

Shu Qian Liu*, Derek Roberts, Alexei Kharitonenkov, Brian Zhang, Samuel M. Hanson, Yan Chun Li, Li-Qun Zhang, Yu H. Wu

*Corresponding author for this work

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Myocardial ischemia, while causing cardiomyocyte injury, can activate innate protective processes, enhancing myocardial tolerance to ischemia. Such processes are present in not only the heart, but also remote organs. In this investigation, we demonstrated a cardioprotective process involving FGF21 from the liver and adipose tissue. In response to myocardial ischemia/reperfusion injury in the mouse, FGF21 was upregulated and released from the hepatic cells and adipocytes into the circulation and interacted with FGFR1 in cardiomyocytes under the mediation of the cell membrane protein β-Klotho, inducing FGFR1 phosphorylation. This action caused phosphorylation of the signaling molecules PI3K p85, Akt1, and BAD, thereby reducing caspase 3 activity, cell death, and myocardial infarction in association with improvement of myocardial function. These observations suggest that FGF21 is upregulated and released from the liver and adipose tissue in myocardial injury, contributing to myocardial protection by the mediation of the FGFR1/β-Klotho-PI3K-Akt1-BAD signaling network.

Original languageEnglish (US)
Article number2767
JournalScientific Reports
Volume3
DOIs
StatePublished - Oct 14 2013

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Adipose Tissue
Myocardium
Phosphatidylinositol 3-Kinases
Cardiac Myocytes
Myocardial Ischemia
Liver
Phosphorylation
Myocardial Reperfusion Injury
Wounds and Injuries
Reperfusion Injury
Adipocytes
Caspase 3
Hepatocytes
Membrane Proteins
Cell Death
Ischemia
Myocardial Infarction
fibroblast growth factor 21

ASJC Scopus subject areas

  • General

Cite this

Liu, S. Q., Roberts, D., Kharitonenkov, A., Zhang, B., Hanson, S. M., Li, Y. C., ... Wu, Y. H. (2013). Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue. Scientific Reports, 3, [2767]. https://doi.org/10.1038/srep02767
Liu, Shu Qian ; Roberts, Derek ; Kharitonenkov, Alexei ; Zhang, Brian ; Hanson, Samuel M. ; Li, Yan Chun ; Zhang, Li-Qun ; Wu, Yu H. / Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue. In: Scientific Reports. 2013 ; Vol. 3.
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Liu, SQ, Roberts, D, Kharitonenkov, A, Zhang, B, Hanson, SM, Li, YC, Zhang, L-Q & Wu, YH 2013, 'Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue', Scientific Reports, vol. 3, 2767. https://doi.org/10.1038/srep02767

Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue. / Liu, Shu Qian; Roberts, Derek; Kharitonenkov, Alexei; Zhang, Brian; Hanson, Samuel M.; Li, Yan Chun; Zhang, Li-Qun; Wu, Yu H.

In: Scientific Reports, Vol. 3, 2767, 14.10.2013.

Research output: Contribution to journalArticle

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