Endogenous proliferation: Burst-like CD4 T cell proliferation in lymphopenic settings

Booki Min*, William E. Paul

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Rapid and slow proliferation is observed when naïve CD4 T cells are transferred into lymphopenic hosts. We have recently proposed that the rapid, burst-like proliferation, designated endogenous proliferation, is a peripheral mechanism by which memory T cells of diverse specificity are generated without exogenous antigenic stimulation. In this review, we discuss some of unique features of endogenous proliferation. We argue that it is regulated not by the absolute number of memory cells present but by the range of specificities of those cells. We discuss the physiologic significance of endogenous proliferation and outline goals for future studies.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalSeminars in Immunology
Issue number3
StatePublished - Jun 2005
Externally publishedYes


  • CD4 T cells
  • Endogenous proliferation
  • Homeostasis
  • Lymphopenia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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