Serdar E Bulun*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations


Endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that primarily affects pelvic tissues, including ovaries, and results from repetitious ovulatory menstrual episodes and retrograde travel and survival of shed endometrial tissue in the lower abdominal cavity. It is the most common cause of chronic pelvic pain in women and is linked with infertility. The key underlying mechanisms affect the intracavitary endometrium and (ectopic) endometriosis tissue; these include poorly differentiated endometrial mesenchymal progenitor/stem cells, widespread epigenetic defects, estrogen receptor-β-mediated activation of inflammation, and progesterone resistance. Pain is managed by the suppression of ovulatory menses and estrogen production, cyclooxygenase inhibitors, and the surgical removal of endometriosis, whereas in vitro fertilization is frequently used to enhance fertility.

Original languageEnglish (US)
Title of host publicationYen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition
PublisherElsevier Inc
ISBN (Electronic)9780323582322
ISBN (Print)9780323479127
StatePublished - Jan 1 2019


  • Aromatase inhibitor
  • Chronic inflammation
  • Endometriosis
  • Endometrium
  • Epigenetic defect
  • Estrogen biosynthesis
  • Estrogen receptor-β
  • GnRH analogue
  • Infertility
  • Laparoscopy
  • Oral contraceptive
  • Pelvic pain
  • Peritoneum
  • Progenitor/stem cells
  • Progesterone resistance

ASJC Scopus subject areas

  • General Medicine


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