Endometriosis

Serdar E Bulun*, Bahar D. Yilmaz, Christia Sison, Kaoru Miyazaki, Lia A Bernardi Wendeln, Shimeng Liu, Amanda Kohlmeier, Ping Yin, Magdy P Milad, Jian-Jun Wei

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. The underlying pathologic mechanisms in the intracavitary endometrium and extrauterine endometriotic tissue involve defectively programmed endometrial mesenchymal progenitor/stem cells. Although endometriotic stromal cells, which compose the bulk of endometriotic lesions, do not carry somatic mutations, they demonstrate specific epigenetic abnormalities that alter expression of key transcription factors. For example, GATA-binding factor-6 overexpression transforms an endometrial stromal cell to an endometriotic phenotype, and steroidogenic factor-1 overexpression causes excessive production of estrogen, which drives inflammation via pathologically high levels of estrogen receptor-β. Progesterone receptor deficiency causes progesterone resistance. Populations of endometrial and endometriotic epithelial cells also harbor multiple cancer driver mutations, such as KRAS, which may be associated with the establishment of pelvic endometriosis or ovarian cancer. It is not known how interactions between epigenomically defective stromal cells and the mutated genes in epithelial cells contribute to the pathogenesis of endometriosis. Endometriosis-associated pelvic pain is managed by suppression of ovulatory menses and estrogen production, cyclooxygenase inhibitors, and surgical removal of pelvic lesions, and in vitro fertilization is frequently used to overcome infertility. Although novel targeted treatments are becoming available, as endometriosis pathophysiology is better understood, preventive approaches such as long-term ovulation suppression may play a critical role in the future.

Original languageEnglish (US)
Pages (from-to)1048-1079
Number of pages32
JournalEndocrine reviews
Volume40
Issue number4
DOIs
StatePublished - May 10 2019

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Endometriosis
Stromal Cells
Estrogens
Pelvic Pain
Mesenchymal Stromal Cells
Infertility
Epithelial Cells
Ovulation Inhibition
Steroidogenic Factor 1
GATA Transcription Factors
Pelvic Neoplasms
Mutation
Menstruation
Cyclooxygenase Inhibitors
Abdominal Cavity
Progesterone Receptors
Fertilization in Vitro
Endometrium
Epigenomics
Chronic Pain

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi Wendeln, L. A., Liu, S., ... Wei, J-J. (2019). Endometriosis. Endocrine reviews, 40(4), 1048-1079. https://doi.org/10.1210/er.2018-00242
Bulun, Serdar E ; Yilmaz, Bahar D. ; Sison, Christia ; Miyazaki, Kaoru ; Bernardi Wendeln, Lia A ; Liu, Shimeng ; Kohlmeier, Amanda ; Yin, Ping ; Milad, Magdy P ; Wei, Jian-Jun. / Endometriosis. In: Endocrine reviews. 2019 ; Vol. 40, No. 4. pp. 1048-1079.
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Bulun, SE, Yilmaz, BD, Sison, C, Miyazaki, K, Bernardi Wendeln, LA, Liu, S, Kohlmeier, A, Yin, P, Milad, MP & Wei, J-J 2019, 'Endometriosis', Endocrine reviews, vol. 40, no. 4, pp. 1048-1079. https://doi.org/10.1210/er.2018-00242

Endometriosis. / Bulun, Serdar E; Yilmaz, Bahar D.; Sison, Christia; Miyazaki, Kaoru; Bernardi Wendeln, Lia A; Liu, Shimeng; Kohlmeier, Amanda; Yin, Ping; Milad, Magdy P; Wei, Jian-Jun.

In: Endocrine reviews, Vol. 40, No. 4, 10.05.2019, p. 1048-1079.

Research output: Contribution to journalReview article

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T1 - Endometriosis

AU - Bulun, Serdar E

AU - Yilmaz, Bahar D.

AU - Sison, Christia

AU - Miyazaki, Kaoru

AU - Bernardi Wendeln, Lia A

AU - Liu, Shimeng

AU - Kohlmeier, Amanda

AU - Yin, Ping

AU - Milad, Magdy P

AU - Wei, Jian-Jun

PY - 2019/5/10

Y1 - 2019/5/10

N2 - Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. The underlying pathologic mechanisms in the intracavitary endometrium and extrauterine endometriotic tissue involve defectively programmed endometrial mesenchymal progenitor/stem cells. Although endometriotic stromal cells, which compose the bulk of endometriotic lesions, do not carry somatic mutations, they demonstrate specific epigenetic abnormalities that alter expression of key transcription factors. For example, GATA-binding factor-6 overexpression transforms an endometrial stromal cell to an endometriotic phenotype, and steroidogenic factor-1 overexpression causes excessive production of estrogen, which drives inflammation via pathologically high levels of estrogen receptor-β. Progesterone receptor deficiency causes progesterone resistance. Populations of endometrial and endometriotic epithelial cells also harbor multiple cancer driver mutations, such as KRAS, which may be associated with the establishment of pelvic endometriosis or ovarian cancer. It is not known how interactions between epigenomically defective stromal cells and the mutated genes in epithelial cells contribute to the pathogenesis of endometriosis. Endometriosis-associated pelvic pain is managed by suppression of ovulatory menses and estrogen production, cyclooxygenase inhibitors, and surgical removal of pelvic lesions, and in vitro fertilization is frequently used to overcome infertility. Although novel targeted treatments are becoming available, as endometriosis pathophysiology is better understood, preventive approaches such as long-term ovulation suppression may play a critical role in the future.

AB - Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. The underlying pathologic mechanisms in the intracavitary endometrium and extrauterine endometriotic tissue involve defectively programmed endometrial mesenchymal progenitor/stem cells. Although endometriotic stromal cells, which compose the bulk of endometriotic lesions, do not carry somatic mutations, they demonstrate specific epigenetic abnormalities that alter expression of key transcription factors. For example, GATA-binding factor-6 overexpression transforms an endometrial stromal cell to an endometriotic phenotype, and steroidogenic factor-1 overexpression causes excessive production of estrogen, which drives inflammation via pathologically high levels of estrogen receptor-β. Progesterone receptor deficiency causes progesterone resistance. Populations of endometrial and endometriotic epithelial cells also harbor multiple cancer driver mutations, such as KRAS, which may be associated with the establishment of pelvic endometriosis or ovarian cancer. It is not known how interactions between epigenomically defective stromal cells and the mutated genes in epithelial cells contribute to the pathogenesis of endometriosis. Endometriosis-associated pelvic pain is managed by suppression of ovulatory menses and estrogen production, cyclooxygenase inhibitors, and surgical removal of pelvic lesions, and in vitro fertilization is frequently used to overcome infertility. Although novel targeted treatments are becoming available, as endometriosis pathophysiology is better understood, preventive approaches such as long-term ovulation suppression may play a critical role in the future.

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Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi Wendeln LA, Liu S et al. Endometriosis. Endocrine reviews. 2019 May 10;40(4):1048-1079. https://doi.org/10.1210/er.2018-00242