Abstract
An endonucleolytic activity has been identified in nuclear extracts of chick embryo bursa and mouse fetal liver cells. The activity introduces a double-strand cut in the vicinity of the recombination site of immunoglobulin joining gene segments. The cleavage occurs at the dinucleotide pair TGAC. This activity is a good candidate for the putative endonuclease involved in recombination of the immunoglobulin variable, diversity, and joining regions. It is distinct from the endonuclease activities previously reported by others.
Original language | English (US) |
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Pages (from-to) | 1141-1145 |
Number of pages | 5 |
Journal | Science |
Volume | 231 |
Issue number | 4742 |
DOIs | |
State | Published - 1986 |
ASJC Scopus subject areas
- General