Endonucleolytic activity that cleaves immunoglobulin recombination sequences

Thomas J. Hope*, Renato J. Aguilera, Mark E. Minie, Hitoshi Sakano

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


An endonucleolytic activity has been identified in nuclear extracts of chick embryo bursa and mouse fetal liver cells. The activity introduces a double-strand cut in the vicinity of the recombination site of immunoglobulin joining gene segments. The cleavage occurs at the dinucleotide pair TGAC. This activity is a good candidate for the putative endonuclease involved in recombination of the immunoglobulin variable, diversity, and joining regions. It is distinct from the endonuclease activities previously reported by others.

Original languageEnglish (US)
Pages (from-to)1141-1145
Number of pages5
Issue number4742
StatePublished - 1986

ASJC Scopus subject areas

  • General

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