Endoplasmic reticulum stress response as a potential therapeutic target in multiple sclerosis

Meghann Teague Getts, Daniel R. Getts, Adam P. Kohm, Stephen D. Miller*

*Corresponding author for this work

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Multiple sclerosis is an inflammatory demyelinating disorder of the CNS. Since current treatments are aimed at nonspecifically downregulating inflammation, and natural mechanisms of repair and remyelination within the CNS are inadequate for recovery of function, multiple sclerosis patients presently only have available treatments that delay symptom progression. The complex nature of this disease means that only multifaceted treatments hold the promise of a cure. Recent studies indicate that the endoplasmic reticulum stress response, a cellular pathway that allows a cell to survive and recovery from a stressful event, could be elicited to help the myelin-generating and myelin-support cells of the CNS survive inflammatory insult.

Original languageEnglish (US)
Pages (from-to)631-640
Number of pages10
JournalTherapy
Volume5
Issue number5
DOIs
StatePublished - Sep 1 2008

Keywords

  • Apoptosis
  • Cell survival
  • Demyelination
  • Endoplasmic reticulum stress response
  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis
  • Myelin repair
  • OPC
  • Oligodendrocytes
  • Remyelination
  • Unfolded protein response

ASJC Scopus subject areas

  • Pharmacology (medical)

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