This Account examines the role of electron-nuclear double resonance (ENDOR) spectroscopy in furthering our understanding of how metal ions function in biological systems. It briefly describes ENDOR and electron spin-echo envelope modulation (ESEEM) spectroscopies and then illustrates the uses of ENDOR with several case studies from our own research: cytochrome c peroxidase compound ES; ribonucleotide reductase intermediate X; allylbenzene-inactivated chloroperoxidase; the role of the [4Fe-4S]+ cluster in enzymes of the "radical S-adenosylmethionine" superfamily; dioxygen activation by heme enzymes. Finally, it briefly considers future developments.
|Original language||English (US)|
|Number of pages||8|
|Journal||Accounts of chemical research|
|State||Published - Jul 1 2003|
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