ENDOR of metalloenzymes

Brian M. Hoffman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


This Account examines the role of electron-nuclear double resonance (ENDOR) spectroscopy in furthering our understanding of how metal ions function in biological systems. It briefly describes ENDOR and electron spin-echo envelope modulation (ESEEM) spectroscopies and then illustrates the uses of ENDOR with several case studies from our own research: cytochrome c peroxidase compound ES; ribonucleotide reductase intermediate X; allylbenzene-inactivated chloroperoxidase; the role of the [4Fe-4S]+ cluster in enzymes of the "radical S-adenosylmethionine" superfamily; dioxygen activation by heme enzymes. Finally, it briefly considers future developments.

Original languageEnglish (US)
Pages (from-to)522-529
Number of pages8
JournalAccounts of chemical research
Issue number7
StatePublished - Jul 1 2003

ASJC Scopus subject areas

  • General Chemistry


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