Endothelial biology in the post-menopausal obese woman

Judith L. Meadows; Douglas E. Vaughan

doi:10.1016/j.maturitas.2011.03.012

Endothelial biology in the post-menopausal obese woman

Judith L. Meadows, Douglas E. Vaughan

Medicine, Cardiology Division

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Women generally have a reduced risk of cardiovascular disease (CVD). However, this protection of gender diminishes rapidly after menopause and with advancing age, particularly in obese women. Alterations in vascular function are thought to a key early step in the development of atherosclerosis. In this review, we will describe the features of endothelial dysfunction in the post-menopausal obese female and discuss the interplay of aging, estrogen withdrawal, and obesity. The objectives include (1) a review of endothelial biology and endothelial dysfunction, and (2) a discussion how the endothelial function is altered in the context of aging, hormonal changes and insulin resistance. The clinical consequences of endothelial dysfunction and CVD will also be reviewed.

Original language	English (US)
Pages (from-to)	120-125
Number of pages	6
Journal	Maturitas
Volume	69
Issue number	2
DOIs	https://doi.org/10.1016/j.maturitas.2011.03.012
State	Published - Jun 2011

Funding

This work was supported in part by grants HL51387 and P50 HL 081009 from the National Institutes of Health , Bethesda, MD.

Keywords

Aging
Cardiovascular disease
Endothelial function
Gender
Menopause
Metabolic syndrome
Nitric oxide
Obesity
Vascular function
Vasodilation

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.maturitas.2011.03.012

Cite this

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abstract = "Women generally have a reduced risk of cardiovascular disease (CVD). However, this protection of gender diminishes rapidly after menopause and with advancing age, particularly in obese women. Alterations in vascular function are thought to a key early step in the development of atherosclerosis. In this review, we will describe the features of endothelial dysfunction in the post-menopausal obese female and discuss the interplay of aging, estrogen withdrawal, and obesity. The objectives include (1) a review of endothelial biology and endothelial dysfunction, and (2) a discussion how the endothelial function is altered in the context of aging, hormonal changes and insulin resistance. The clinical consequences of endothelial dysfunction and CVD will also be reviewed.",

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note = "Funding Information: This work was supported in part by grants HL51387 and P50 HL 081009 from the National Institutes of Health , Bethesda, MD. ",

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AU - Meadows, Judith L.

AU - Vaughan, Douglas E.

N1 - Funding Information: This work was supported in part by grants HL51387 and P50 HL 081009 from the National Institutes of Health , Bethesda, MD.

PY - 2011/6

Y1 - 2011/6

N2 - Women generally have a reduced risk of cardiovascular disease (CVD). However, this protection of gender diminishes rapidly after menopause and with advancing age, particularly in obese women. Alterations in vascular function are thought to a key early step in the development of atherosclerosis. In this review, we will describe the features of endothelial dysfunction in the post-menopausal obese female and discuss the interplay of aging, estrogen withdrawal, and obesity. The objectives include (1) a review of endothelial biology and endothelial dysfunction, and (2) a discussion how the endothelial function is altered in the context of aging, hormonal changes and insulin resistance. The clinical consequences of endothelial dysfunction and CVD will also be reviewed.

AB - Women generally have a reduced risk of cardiovascular disease (CVD). However, this protection of gender diminishes rapidly after menopause and with advancing age, particularly in obese women. Alterations in vascular function are thought to a key early step in the development of atherosclerosis. In this review, we will describe the features of endothelial dysfunction in the post-menopausal obese female and discuss the interplay of aging, estrogen withdrawal, and obesity. The objectives include (1) a review of endothelial biology and endothelial dysfunction, and (2) a discussion how the endothelial function is altered in the context of aging, hormonal changes and insulin resistance. The clinical consequences of endothelial dysfunction and CVD will also be reviewed.

KW - Aging

KW - Cardiovascular disease

KW - Endothelial function

KW - Gender

KW - Menopause

KW - Metabolic syndrome

KW - Nitric oxide

KW - Obesity

KW - Vascular function

KW - Vasodilation

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Endothelial biology in the post-menopausal obese woman

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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