Endothelial biology in the post-menopausal obese woman

Judith L. Meadows, Douglas E. Vaughan

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Women generally have a reduced risk of cardiovascular disease (CVD). However, this protection of gender diminishes rapidly after menopause and with advancing age, particularly in obese women. Alterations in vascular function are thought to a key early step in the development of atherosclerosis. In this review, we will describe the features of endothelial dysfunction in the post-menopausal obese female and discuss the interplay of aging, estrogen withdrawal, and obesity. The objectives include (1) a review of endothelial biology and endothelial dysfunction, and (2) a discussion how the endothelial function is altered in the context of aging, hormonal changes and insulin resistance. The clinical consequences of endothelial dysfunction and CVD will also be reviewed.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalMaturitas
Volume69
Issue number2
DOIs
StatePublished - Jun 2011

Keywords

  • Aging
  • Cardiovascular disease
  • Endothelial function
  • Gender
  • Menopause
  • Metabolic syndrome
  • Nitric oxide
  • Obesity
  • Vascular function
  • Vasodilation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynecology

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