Endothelial cell activation following moderate traumatic brain injury

R. Balabanov, H. Goldman, S. Murphy, G. Pellizon, C. Owen, J. Rafols, P. Dore-Duffy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Traumatic brain injury (TBI) initiates a cascade of acute and chronic injury responses which include disturbances in the cerebrovasculature that may result in the activation of the microvascular endothelial development of a dysfunction endothelium. The present study examines endothelial cell (EC) activation in a percussion model of moderate TBI. The criteria for endothelial activation used in these studies was surface expression of a number of markers collectively termed endothelial activation antigens. Temporal induction of the major histocompatibility (MHC) class II molecules, E-selectin (CD62E), vascular cell adhesion molecule (VACM-1) (CD106) as well as altered expression of constitutively expressed intercellular adhesion molecule-1 (ICAM-1) (CD54), the glucose transporter protein (glut-1), the transferrin receptor (tfR) (CD71), and MHC class I molecules was examined at various times following impact. Induction of E-selectin and increased expression of ICAM-1 was seen by 2 h post-impact (PI) and was sustained through 24 h PI. Decreased expression of immunologically reactive glut-1 and tfR was observed by 2-4 h PI and remained Iow up to 24 h PI. No induction of VCAM-1, MHC class II molecules or altered constitutive expression or MHC class I molecules was seen. Changes in EC activation were observed predominantly at the site of impact and were diminished temporarily. These results indicate that mild concussive injury to the brain results in activation of the endothelium.

Original languageEnglish (US)
Pages (from-to)175-182
Number of pages8
JournalNeurological research
Issue number2-3
StatePublished - Apr 23 2001


  • Adhesion molecules
  • E-selectin
  • Endothelial cell activation
  • Glucose transporter
  • ICAM-1
  • Transferrin receptor
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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