Endothelial cell plasticity: How to become and remain a lymphatic endothelial cell

Guillermo Oliver*, R. Sathish Srinivasan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

116 Scopus citations


Lineage commitment and differentiation into mature cell types are mostly considered to be unidirectional and irreversible processes. However, recent results have challenged this by showing that terminally differentiated cell types can be reprogrammed into other cell types, an important step towards devising strategies for gene therapy and tissue regeneration. In this Review, we summarize recent data on the earliest steps in the development of the mammalian lymphatic vasculature: the specification of lymphatic endothelial cells (LECs). We elaborate on a developmental model that integrates the different steps leading to LEC differentiation and lymphatic network formation, discuss evidence that suggests that LEC fate is plastic, and consider the potentially far-reaching implications of the ability to convert one cell type into another.

Original languageEnglish (US)
Pages (from-to)363-372
Number of pages10
Issue number3
StatePublished - Feb 1 2010


  • Cell differentiation
  • Cell plasticity
  • Endothelial cell
  • Lymphatics
  • Prox1

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology


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