Endothelial-mesenchymal transition in vascular calcification of Ins2Akita/+ Mice

Pierre J. Guihard, Jiayi Yao, Ana M. Blazquez-Medela, Luisa Iruela-Arispe, Kristina I. Boström, Yucheng Yao

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification. We also find an induction of a complex of serine proteases in the diabetic endothelium, required for the up-regulation of Sox2. Our results suggest that EndMTs contribute to vascular calcification in diabetic arteries.

Original languageEnglish (US)
Article numbere0167936
JournalPloS one
Volume11
Issue number12
DOIs
StatePublished - Dec 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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