Endothelial uptake of fentanyl occurs by both diffusional and specific transporter pathways

Christopher M. Waters, Tom C Krejcie, Michael J Avram

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The mechanisms of the specific uptake of fentanyl were investigated using human lung microvascular endothelia cells. Cellular uptake of fentanyl was modeled with two pathways. Uptake by passive diffusion was characterized by rapid partitioning between the supernatant fluid and a cellular diffusion compartment using a partition coefficient. Specific uptake of fentanyl by a transporter was characterized by a rate constant for binding to the transporter. The results demonstrate that human lung microvascular endothelial cells are capable of active uptake and sequestering of fentanyl.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages285-286
Number of pages2
Volume42
ISBN (Print)0791816117
StatePublished - Dec 1 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999

Other

Other1999 Bioengineering Conference
CityBig Sky, MT, USA
Period6/16/996/20/99

ASJC Scopus subject areas

  • Engineering(all)

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