Abstract
The mechanisms of the specific uptake of fentanyl were investigated using human lung microvascular endothelia cells. Cellular uptake of fentanyl was modeled with two pathways. Uptake by passive diffusion was characterized by rapid partitioning between the supernatant fluid and a cellular diffusion compartment using a partition coefficient. Specific uptake of fentanyl by a transporter was characterized by a rate constant for binding to the transporter. The results demonstrate that human lung microvascular endothelial cells are capable of active uptake and sequestering of fentanyl.
| Original language | English (US) |
|---|---|
| Title of host publication | American Society of Mechanical Engineers, Bioengineering Division (Publication) BED |
| Publisher | ASME |
| Pages | 285-286 |
| Number of pages | 2 |
| Volume | 42 |
| ISBN (Print) | 0791816117 |
| State | Published - 1999 |
| Event | 1999 Bioengineering Conference - Big Sky, MT, USA Duration: Jun 16 1999 → Jun 20 1999 |
Other
| Other | 1999 Bioengineering Conference |
|---|---|
| City | Big Sky, MT, USA |
| Period | 6/16/99 → 6/20/99 |
ASJC Scopus subject areas
- General Engineering