Endothelin-1 contributes to the development of virus-induced demyelinating disease

Young Hee Jin*, Bongsu Kang, Hyun S. Kang, Chang Sung Koh, Byung S. Kim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Experimental autoimmune encephalitis (EAE) and virally induced demyelinating disease are two major experimental model systems used to study human multiple sclerosis. Although endothelin-1 level elevation was previously observed in the CNS of mice with EAE and viral demyelinating disease, the potential role of endothelin-1 in the development of these demyelinating diseases is unknown. Methods and results: In this study, the involvement of endothelin-1 in the development and progression of demyelinating diseases was investigated using these two experimental models. Administration of endothelin-1 significantly promoted the progression of both experimental diseases accompanied with elevated inflammatory T cell responses. In contrast, administration of specific endothelin-1 inhibitors (BQ610 and BQ788) significantly inhibited progression of these diseases accompanied with reduced T cell responses to the respective antigens. Conclusions: These results strongly suggest that the level of endothelin-1 plays an important role in the pathogenesis of immune-mediated CNS demyelinating diseases by promoting immune responses.

Original languageEnglish (US)
Article number307
JournalJournal of neuroinflammation
Volume17
Issue number1
DOIs
StatePublished - Dec 1 2020

Keywords

  • CNS
  • Demyelination
  • EAE
  • Endothelin-1
  • TMEV

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Neurology
  • Cellular and Molecular Neuroscience

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