Background: Experimental autoimmune encephalitis (EAE) and virally induced demyelinating disease are two major experimental model systems used to study human multiple sclerosis. Although endothelin-1 level elevation was previously observed in the CNS of mice with EAE and viral demyelinating disease, the potential role of endothelin-1 in the development of these demyelinating diseases is unknown. Methods and results: In this study, the involvement of endothelin-1 in the development and progression of demyelinating diseases was investigated using these two experimental models. Administration of endothelin-1 significantly promoted the progression of both experimental diseases accompanied with elevated inflammatory T cell responses. In contrast, administration of specific endothelin-1 inhibitors (BQ610 and BQ788) significantly inhibited progression of these diseases accompanied with reduced T cell responses to the respective antigens. Conclusions: These results strongly suggest that the level of endothelin-1 plays an important role in the pathogenesis of immune-mediated CNS demyelinating diseases by promoting immune responses.
|Original language||English (US)|
|Journal||Journal of neuroinflammation|
|State||Published - Dec 1 2020|
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
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Endothelin-1 contributes to the development of virus-induced demyelinating disease
Jin, Y. (Creator), Kang, B. (Creator), Kang, H. S. (Creator), Koh, C. (Creator) & Kim, B. S. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.5178507.v1, https://springernature.figshare.com/collections/Endothelin-1_contributes_to_the_development_of_virus-induced_demyelinating_disease/5178507/1