Abstract
Background: Experimental autoimmune encephalitis (EAE) and virally induced demyelinating disease are two major experimental model systems used to study human multiple sclerosis. Although endothelin-1 level elevation was previously observed in the CNS of mice with EAE and viral demyelinating disease, the potential role of endothelin-1 in the development of these demyelinating diseases is unknown. Methods and results: In this study, the involvement of endothelin-1 in the development and progression of demyelinating diseases was investigated using these two experimental models. Administration of endothelin-1 significantly promoted the progression of both experimental diseases accompanied with elevated inflammatory T cell responses. In contrast, administration of specific endothelin-1 inhibitors (BQ610 and BQ788) significantly inhibited progression of these diseases accompanied with reduced T cell responses to the respective antigens. Conclusions: These results strongly suggest that the level of endothelin-1 plays an important role in the pathogenesis of immune-mediated CNS demyelinating diseases by promoting immune responses.
Original language | English (US) |
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Article number | 307 |
Journal | Journal of neuroinflammation |
Volume | 17 |
Issue number | 1 |
DOIs | |
State | Published - Dec 1 2020 |
Keywords
- CNS
- Demyelination
- EAE
- Endothelin-1
- TMEV
ASJC Scopus subject areas
- Neuroscience(all)
- Immunology
- Neurology
- Cellular and Molecular Neuroscience