Endotoxemia and the effects of dopamine on renal functions of neonatal piglets

Anthony Chin, Linh Nguyen O'conner, Jayant Radhakrishnan*, Linda Fornell, Eunice John

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In this study, we observed the effects of moderate and high doses of dopamine on the renal functions of neonatal piglets during endotoxic shock. We found that fluid therapy alone was better at maintaining cardiac index and preventing elevation of systemic vascular resistance, than dopamine at 10 and at 20 μg/kg/min. Furthermore, urine output and glomerular filtration rate were reduced by dopamine. Following endotoxin administration dopamine decreased SVR and maintained a CI better than fluid alone. However, in spite of a better CI, greater deterioration in renal functions occurred in the dopamine groups as compared to the fluid group.

Original languageEnglish (US)
Pages (from-to)196-202
Number of pages7
JournalBiology of the Neonate
Volume81
Issue number3
DOIs
StatePublished - Apr 20 2002

Keywords

  • Dopamine
  • Endotoxemia
  • Neonate
  • Renal function
  • Sepsis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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