Engineered reproductive tissues

Emma S. Gargus, Hunter B. Rogers, Kelly E. McKinnon, Maxwell E. Edmonds, Teresa K. Woodruff*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Engineered male and female biomimetic reproductive tissues are being developed as autonomous in vitro units or as integrated multi-organ in vitro systems to support germ cell and embryo function, and to display characteristic endocrine phenotypic patterns, such as the 28-day human ovulatory cycle. In this Review, we summarize how engineered reproductive tissues facilitate research in reproductive biology, and overview strategies for making engineered reproductive tissues that might eventually allow the restoration of reproductive capacity in patients.

Original languageEnglish (US)
Pages (from-to)381-393
Number of pages13
JournalNature Biomedical Engineering
Volume4
Issue number4
DOIs
StatePublished - Apr 1 2020

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

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