Abstract
One-carbon (C1) greenhouse gases are the primary driver of global climate change. Fermenting these gases into higher-value products is an attractive strategy for climate action and sustainable development. C1 gas-fermenting bacteria are promising chassis organisms, but various technical challenges hinder scale-up to industrial production levels. Bacterial microcompartments (MCPs), proteinaceous organelles that encapsulate enzymatic pathways, may confer several metabolic benefits to increase the industrial potential of these bacteria. Many species of gas-fermenting bacteria are already predicted to natively produce MCPs. Here, we describe how these organelles can be identified and engineered to encapsulate pathways that convert C1 gases into valuable chemical products.
| Original language | English (US) |
|---|---|
| Article number | 103299 |
| Journal | Current Opinion in Biotechnology |
| Volume | 93 |
| DOIs | |
| State | Published - Jun 2025 |
Funding
We thank members of the Tullman-Ercek lab for their helpful discussions and support throughout the preparation of this manuscript. E.R.J. was funded in part by the Northwestern University Synthesizing Biology Across Scales program, a National Science Foundation National Research Traineeship program (NSF DGE-2021900). E.R.J. and D.T.E. were funded by the Northwestern University Materials Science and Engineering Center (NSF DMR-2308691) and a grant from the Department of Energy (DE-SC0022180). M.R.J. was supported by the National Science Foundation Graduate Research Fellowship Program (NSF DGE-2234667). \u201CFactory\u201D symbol in the graphical abstract is by Kevin from thenounproject.com. We thank members of the Tullman-Ercek lab for their helpful discussions and support throughout the preparation of this manuscript. E.R.J. was funded in part by the Northwestern University Synthesizing Biology Across Scales program, a United States National Science Foundation (NSF) Research Traineeship program (NSF DGE-2021900). E.R.J. and D.T.E. were funded by the Northwestern University Materials Science and Engineering Center (NSF DMR-2308691) and a grant from the United States Department of Energy (DE-SC0022180). M.R.J. was supported by the NSF Graduate Research Fellowship Program (NSF DGE-2234667). \u2018Factory\u2019 symbol in the graphical abstract is by Kevin from thenounproject.com.
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
