73 Scopus citations


Nanoshells are a novel class of optically tunable nanoparticles that consist of alternating dielectric and metal layers. They can potentially be used as contrast agents for multi-label molecular imaging, provided that the shell thicknesses are tuned to specific ratios. Sub-100nm multi-layer nanoshells can potentially have improved tissue penetration, generate a strong surface plasmon resonance, and may exhibit absorption peaks in the visible-near-infrared (NIR) spectrum. Herein we describe the synthesis and characterization of bilayered concentric nanoshells with an overall diameter of around 50nm consisting of a gold core, a tunable silica spacer layer and an outermost gold shell, which is approximately 16 times smaller than previously described multi-layered nanoparticles. The structured nanoshells were visualized by transmission electron microscopy (TEM) at each step of preparation. The absorption spectra of the gold-silica bilayered nanoshells are in good agreement with Mie's prediction and their resonance peak position is a function of the relative thickness of silica and gold layers.

Original languageEnglish (US)
Article number025
Pages (from-to)5435-5440
Number of pages6
Issue number21
StatePublished - Nov 14 2006

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering


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