Engraftment syndrome: A common cause for rash and fever following autologous hematopoietic stem cell transplantation for multiple sclerosis

Y. Oyama, B. Cohen, A. Traynor, M. Brush, J. Rodriguez, R. K. Burt

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Autologous hematopoietic stem cell transplantation (HSCT) is currently being evaluated as a therapy for patients with progressive multiple sclerosis (MS) at risk of debilitating neurological impairment. While preliminary results from a few studies have been reported, little is known about toxicities or outcome of HSCT for MS. We report a relatively frequent triad of non-infectious fever, rash and fatigue or lassitude that may also be associated with pruritis, pulmonary symptoms, and eosinophilia and frequently occurs around engraftment. This syndrome occurred in 26% of our series of patients (5/19) undergoing HSCT for multiple sclerosis. The engraftment syndrome is usually self-limited but may require intervention with systemic corticosteroids.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalBone Marrow Transplantation
Volume29
Issue number1
DOIs
StatePublished - 2002

Keywords

  • Autologous transplantation
  • Engraftment syndrome
  • Eosinophilia
  • Multiple sclerosis
  • Skin rash

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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