Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers

Wenzhi Ren, Leyong Zeng, Zheyu Shen, Lingchao Xiang, An Gong, Jichao Zhang, Chengwen Mao, Aiguo Li, Tatjana Paunesku, Gayle E. Woloschak, Narayan S. Hosmane, Aiguo Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

In order to overcome the multidrug resistance of breast cancer cells, doxorubicin was loaded onto TiO2 nanoparticles in which the electrostatic interactions hold the drug and the nanoparticles together. The anticancer activity of this nanocomposite was evaluated in multidrug resistant breast cancer cells. In nanocomposite treated MCF-7/ADM cells, drug accumulation increased with enhanced anticancer activity about 2.4 times compared to that of doxorubicin alone. The potential mechanism of enhanced drug accumulation is ascribed to the fact that the nanocomposite directly transports the drugs into cells via internalization, bypassing the P-glycoprotein mediated doxorubicin pumping system. Our results reinforce that the nanocomposite, as a pH controlled drug release system, could be used to overcome multidrug resistance of human breast cancer cells.

Original languageEnglish (US)
Pages (from-to)20855-20861
Number of pages7
JournalRSC Advances
Volume3
Issue number43
DOIs
StatePublished - Nov 21 2013

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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