Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers

Wenzhi Ren; Leyong Zeng; Zheyu Shen; Lingchao Xiang; An Gong; Jichao Zhang; Chengwen Mao; Aiguo Li; Tatjana Paunesku; Gayle E. Woloschak; Narayan S. Hosmane; Aiguo Wu

doi:10.1039/c3ra42863j

Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO₂ nanocarriers

Wenzhi Ren, Leyong Zeng, Zheyu Shen, Lingchao Xiang, An Gong, Jichao Zhang, Chengwen Mao, Aiguo Li, Tatjana Paunesku, Gayle E. Woloschak, Narayan S. Hosmane, Aiguo Wu^*

^*Corresponding author for this work

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

In order to overcome the multidrug resistance of breast cancer cells, doxorubicin was loaded onto TiO₂ nanoparticles in which the electrostatic interactions hold the drug and the nanoparticles together. The anticancer activity of this nanocomposite was evaluated in multidrug resistant breast cancer cells. In nanocomposite treated MCF-7/ADM cells, drug accumulation increased with enhanced anticancer activity about 2.4 times compared to that of doxorubicin alone. The potential mechanism of enhanced drug accumulation is ascribed to the fact that the nanocomposite directly transports the drugs into cells via internalization, bypassing the P-glycoprotein mediated doxorubicin pumping system. Our results reinforce that the nanocomposite, as a pH controlled drug release system, could be used to overcome multidrug resistance of human breast cancer cells.

Original language	English (US)
Pages (from-to)	20855-20861
Number of pages	7
Journal	RSC Advances
Volume	3
Issue number	43
DOIs	https://doi.org/10.1039/c3ra42863j
State	Published - Nov 21 2013

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c3ra42863j

Cite this

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title = "Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers",

abstract = "In order to overcome the multidrug resistance of breast cancer cells, doxorubicin was loaded onto TiO2 nanoparticles in which the electrostatic interactions hold the drug and the nanoparticles together. The anticancer activity of this nanocomposite was evaluated in multidrug resistant breast cancer cells. In nanocomposite treated MCF-7/ADM cells, drug accumulation increased with enhanced anticancer activity about 2.4 times compared to that of doxorubicin alone. The potential mechanism of enhanced drug accumulation is ascribed to the fact that the nanocomposite directly transports the drugs into cells via internalization, bypassing the P-glycoprotein mediated doxorubicin pumping system. Our results reinforce that the nanocomposite, as a pH controlled drug release system, could be used to overcome multidrug resistance of human breast cancer cells.",

author = "Wenzhi Ren and Leyong Zeng and Zheyu Shen and Lingchao Xiang and An Gong and Jichao Zhang and Chengwen Mao and Aiguo Li and Tatjana Paunesku and Woloschak, {Gayle E.} and Hosmane, {Narayan S.} and Aiguo Wu",

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doi = "10.1039/c3ra42863j",

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T1 - Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers

AU - Ren, Wenzhi

AU - Zeng, Leyong

AU - Shen, Zheyu

AU - Xiang, Lingchao

AU - Gong, An

AU - Zhang, Jichao

AU - Mao, Chengwen

AU - Li, Aiguo

AU - Paunesku, Tatjana

AU - Woloschak, Gayle E.

AU - Hosmane, Narayan S.

AU - Wu, Aiguo

PY - 2013/11/21

Y1 - 2013/11/21

N2 - In order to overcome the multidrug resistance of breast cancer cells, doxorubicin was loaded onto TiO2 nanoparticles in which the electrostatic interactions hold the drug and the nanoparticles together. The anticancer activity of this nanocomposite was evaluated in multidrug resistant breast cancer cells. In nanocomposite treated MCF-7/ADM cells, drug accumulation increased with enhanced anticancer activity about 2.4 times compared to that of doxorubicin alone. The potential mechanism of enhanced drug accumulation is ascribed to the fact that the nanocomposite directly transports the drugs into cells via internalization, bypassing the P-glycoprotein mediated doxorubicin pumping system. Our results reinforce that the nanocomposite, as a pH controlled drug release system, could be used to overcome multidrug resistance of human breast cancer cells.

AB - In order to overcome the multidrug resistance of breast cancer cells, doxorubicin was loaded onto TiO2 nanoparticles in which the electrostatic interactions hold the drug and the nanoparticles together. The anticancer activity of this nanocomposite was evaluated in multidrug resistant breast cancer cells. In nanocomposite treated MCF-7/ADM cells, drug accumulation increased with enhanced anticancer activity about 2.4 times compared to that of doxorubicin alone. The potential mechanism of enhanced drug accumulation is ascribed to the fact that the nanocomposite directly transports the drugs into cells via internalization, bypassing the P-glycoprotein mediated doxorubicin pumping system. Our results reinforce that the nanocomposite, as a pH controlled drug release system, could be used to overcome multidrug resistance of human breast cancer cells.

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