Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in IM

Amy G. Kuo; Grace Lee; Bridget M. McKay; John F. Disterhoft

doi:10.1016/j.nlm.2007.07.002

Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in I_M

Amy G. Kuo^*, Grace Lee, Bridget M. McKay, John F. Disterhoft

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Previous work done by our laboratory has demonstrated a reduction of the post-burst afterhyperpolarization (AHP) and accommodation following trace eyeblink conditioning in rabbit CA1 pyramidal neurons. Our laboratory has also demonstrated a reduction in the AHP in rat CA1 pyramidal neurons following spatial learning. In the current study we have extended our findings in rabbits by showing a reduction in both the AHP and accommodation in F344 X BN rat CA1 pyramidal neurons following acquisition of trace eyeblink conditioning. A component current of the AHP, I_M, was evaluated with a specific blocker of this current, and showed no apparent contribution to the learning-related increase in neuronal excitability. Rather, a reduction in an isoproterenol-sensitive component of the AHP, presumably sI_AHP, was observed to underlie the learning-specific change.

Original language	English (US)
Pages (from-to)	125-133
Number of pages	9
Journal	Neurobiology of Learning and Memory
Volume	89
Issue number	2
DOIs	https://doi.org/10.1016/j.nlm.2007.07.002
State	Published - Feb 2008

Keywords

Afterhyperpolarization
Calcium-activated potassium currents
Hippocampus
I
Learning
Neuronal excitability
sI

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Cognitive Neuroscience
Behavioral Neuroscience

Access to Document

10.1016/j.nlm.2007.07.002

Cite this

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title = "Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in IM",

abstract = "Previous work done by our laboratory has demonstrated a reduction of the post-burst afterhyperpolarization (AHP) and accommodation following trace eyeblink conditioning in rabbit CA1 pyramidal neurons. Our laboratory has also demonstrated a reduction in the AHP in rat CA1 pyramidal neurons following spatial learning. In the current study we have extended our findings in rabbits by showing a reduction in both the AHP and accommodation in F344 X BN rat CA1 pyramidal neurons following acquisition of trace eyeblink conditioning. A component current of the AHP, IM, was evaluated with a specific blocker of this current, and showed no apparent contribution to the learning-related increase in neuronal excitability. Rather, a reduction in an isoproterenol-sensitive component of the AHP, presumably sIAHP, was observed to underlie the learning-specific change.",

keywords = "Afterhyperpolarization, Calcium-activated potassium currents, Hippocampus, I, Learning, Neuronal excitability, sI",

author = "Kuo, {Amy G.} and Grace Lee and McKay, {Bridget M.} and Disterhoft, {John F.}",

note = "Funding Information: This work was supported by the National Institutes of Health Grants F31 MH12761 (A.G.K.) and R37 AG08796 (J.F.D.). ",

year = "2008",

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doi = "10.1016/j.nlm.2007.07.002",

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AU - Kuo, Amy G.

AU - Lee, Grace

AU - McKay, Bridget M.

AU - Disterhoft, John F.

N1 - Funding Information: This work was supported by the National Institutes of Health Grants F31 MH12761 (A.G.K.) and R37 AG08796 (J.F.D.).

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