Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in IM

Amy G. Kuo*, Grace Lee, Bridget M. McKay, John F Disterhoft

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Previous work done by our laboratory has demonstrated a reduction of the post-burst afterhyperpolarization (AHP) and accommodation following trace eyeblink conditioning in rabbit CA1 pyramidal neurons. Our laboratory has also demonstrated a reduction in the AHP in rat CA1 pyramidal neurons following spatial learning. In the current study we have extended our findings in rabbits by showing a reduction in both the AHP and accommodation in F344 X BN rat CA1 pyramidal neurons following acquisition of trace eyeblink conditioning. A component current of the AHP, IM, was evaluated with a specific blocker of this current, and showed no apparent contribution to the learning-related increase in neuronal excitability. Rather, a reduction in an isoproterenol-sensitive component of the AHP, presumably sIAHP, was observed to underlie the learning-specific change.

Original languageEnglish (US)
Pages (from-to)125-133
Number of pages9
JournalNeurobiology of Learning and Memory
Volume89
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Afterhyperpolarization
  • Calcium-activated potassium currents
  • Hippocampus
  • I
  • Learning
  • Neuronal excitability
  • sI

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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